Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 73
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::printArticle() - APP/Controller/ArtileDetailController.php, line 73
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 610
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 74
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::printArticle() - APP/Controller/ArtileDetailController.php, line 74
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 610
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 162
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\AssetMiddleware::__invoke() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 88
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Warning (512): Unable to emit headers. Headers sent in file=/home/brlfuser/public_html/vendor/cakephp/cakephp/src/Error/Debugger.php line=853 [CORE/src/Http/ResponseEmitter.php, line 48]
Code Context
            if (Configure::read('debug')) {

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-The Hindu
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&lt;br /&gt;
That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June 18 nor its revocation a month later with a requirement that the medicine be sold with a boxed warning highlighting the adverse side-effect of bladder cancer was based on any scientific evidence from India. The excessive haste and utter secrecy in which the drug was banned raises serious concerns about the decision-making process. It is shocking that eight &amp;lsquo;cases&#039; of bladder cancer in patients who are on pioglitazone was the only &amp;lsquo;data&#039; the ministry relied on to ban a drug that has been used by a sizeable number of diabetics for about a decade. As if the statistically insignificant number of &amp;lsquo;cases&#039; it relied on to take a decision was not shocking enough, it relied on &amp;lsquo;data&#039; that never came under scientific scrutiny. This best portrays how cavalier policymakers can be. If the basis on which the drug was banned is baffling, the grounds on which the ban was revoked with a box warning is puzzling. After all, an Indian study of 958 patients who are on pioglitazone but with no cancer after two years of treatment is the only scientifically valid data currently available. It is also well known that Indians have a different genetic profile from Caucasians and very contrasting characteristics, which make them more susceptible to diabetes.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
While a few large studies conducted elsewhere have shown increased risk, a few others have not. The fact that three countries have placed varying restrictions on the drug&#039;s use should have prompted Indian officials to conduct large-scale studies. Even now, there are overwhelming compulsions to immediately undertake such studies to know the actual risk. Any decision to continue with, remove or rephrase the contents of the boxed warning should be based on those results. Last month&#039;s decision by an advisory panel to the U.S. Food and Drug Administration to &amp;quot;ease restrictions&amp;quot; on the sale of Avandia (rosiglitazone), a much maligned diabetes drug, is a case in point. Avandia was found to increase the risk of heart failure and death. But a re-evaluation has led to a softening of stand. Tobacco being a leading cause of bladder cancer is well known. With millions of tobacco users in the country, only well-designed studies can help in pinpointing the pioglitazone-cancer causative association. The cheap and effective drug has been in the market for about a decade and many thousands have been using it for a long duration and at lower dosages than in the West. The government may have the power to act but Indian diabetics have the right to an informed decision. 
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That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June..."/>
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                <strong>Let the science decide</strong></h1>
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                <div align="justify">-The Hindu</div><p align="justify"><br />That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June 18 nor its revocation a month later with a requirement that the medicine be sold with a boxed warning highlighting the adverse side-effect of bladder cancer was based on any scientific evidence from India. The excessive haste and utter secrecy in which the drug was banned raises serious concerns about the decision-making process. It is shocking that eight &lsquo;cases' of bladder cancer in patients who are on pioglitazone was the only &lsquo;data' the ministry relied on to ban a drug that has been used by a sizeable number of diabetics for about a decade. As if the statistically insignificant number of &lsquo;cases' it relied on to take a decision was not shocking enough, it relied on &lsquo;data' that never came under scientific scrutiny. This best portrays how cavalier policymakers can be. If the basis on which the drug was banned is baffling, the grounds on which the ban was revoked with a box warning is puzzling. After all, an Indian study of 958 patients who are on pioglitazone but with no cancer after two years of treatment is the only scientifically valid data currently available. It is also well known that Indians have a different genetic profile from Caucasians and very contrasting characteristics, which make them more susceptible to diabetes.</p><p align="justify">While a few large studies conducted elsewhere have shown increased risk, a few others have not. The fact that three countries have placed varying restrictions on the drug's use should have prompted Indian officials to conduct large-scale studies. Even now, there are overwhelming compulsions to immediately undertake such studies to know the actual risk. Any decision to continue with, remove or rephrase the contents of the boxed warning should be based on those results. Last month's decision by an advisory panel to the U.S. Food and Drug Administration to &quot;ease restrictions&quot; on the sale of Avandia (rosiglitazone), a much maligned diabetes drug, is a case in point. Avandia was found to increase the risk of heart failure and death. But a re-evaluation has led to a softening of stand. Tobacco being a leading cause of bladder cancer is well known. With millions of tobacco users in the country, only well-designed studies can help in pinpointing the pioglitazone-cancer causative association. The cheap and effective drug has been in the market for about a decade and many thousands have been using it for a long duration and at lower dosages than in the West. The government may have the power to act but Indian diabetics have the right to an informed decision. </p>               </font>
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-The Hindu
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&lt;br /&gt;
That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June 18 nor its revocation a month later with a requirement that the medicine be sold with a boxed warning highlighting the adverse side-effect of bladder cancer was based on any scientific evidence from India. The excessive haste and utter secrecy in which the drug was banned raises serious concerns about the decision-making process. It is shocking that eight &amp;lsquo;cases&#039; of bladder cancer in patients who are on pioglitazone was the only &amp;lsquo;data&#039; the ministry relied on to ban a drug that has been used by a sizeable number of diabetics for about a decade. As if the statistically insignificant number of &amp;lsquo;cases&#039; it relied on to take a decision was not shocking enough, it relied on &amp;lsquo;data&#039; that never came under scientific scrutiny. This best portrays how cavalier policymakers can be. If the basis on which the drug was banned is baffling, the grounds on which the ban was revoked with a box warning is puzzling. After all, an Indian study of 958 patients who are on pioglitazone but with no cancer after two years of treatment is the only scientifically valid data currently available. It is also well known that Indians have a different genetic profile from Caucasians and very contrasting characteristics, which make them more susceptible to diabetes.
&lt;/p&gt;
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While a few large studies conducted elsewhere have shown increased risk, a few others have not. The fact that three countries have placed varying restrictions on the drug&#039;s use should have prompted Indian officials to conduct large-scale studies. Even now, there are overwhelming compulsions to immediately undertake such studies to know the actual risk. Any decision to continue with, remove or rephrase the contents of the boxed warning should be based on those results. Last month&#039;s decision by an advisory panel to the U.S. Food and Drug Administration to &amp;quot;ease restrictions&amp;quot; on the sale of Avandia (rosiglitazone), a much maligned diabetes drug, is a case in point. Avandia was found to increase the risk of heart failure and death. But a re-evaluation has led to a softening of stand. Tobacco being a leading cause of bladder cancer is well known. With millions of tobacco users in the country, only well-designed studies can help in pinpointing the pioglitazone-cancer causative association. The cheap and effective drug has been in the market for about a decade and many thousands have been using it for a long duration and at lower dosages than in the West. The government may have the power to act but Indian diabetics have the right to an informed decision. 
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                <strong>Let the science decide</strong></h1>
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                <div align="justify">-The Hindu</div><p align="justify"><br />That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June 18 nor its revocation a month later with a requirement that the medicine be sold with a boxed warning highlighting the adverse side-effect of bladder cancer was based on any scientific evidence from India. The excessive haste and utter secrecy in which the drug was banned raises serious concerns about the decision-making process. It is shocking that eight &lsquo;cases' of bladder cancer in patients who are on pioglitazone was the only &lsquo;data' the ministry relied on to ban a drug that has been used by a sizeable number of diabetics for about a decade. As if the statistically insignificant number of &lsquo;cases' it relied on to take a decision was not shocking enough, it relied on &lsquo;data' that never came under scientific scrutiny. This best portrays how cavalier policymakers can be. If the basis on which the drug was banned is baffling, the grounds on which the ban was revoked with a box warning is puzzling. After all, an Indian study of 958 patients who are on pioglitazone but with no cancer after two years of treatment is the only scientifically valid data currently available. It is also well known that Indians have a different genetic profile from Caucasians and very contrasting characteristics, which make them more susceptible to diabetes.</p><p align="justify">While a few large studies conducted elsewhere have shown increased risk, a few others have not. The fact that three countries have placed varying restrictions on the drug's use should have prompted Indian officials to conduct large-scale studies. Even now, there are overwhelming compulsions to immediately undertake such studies to know the actual risk. Any decision to continue with, remove or rephrase the contents of the boxed warning should be based on those results. Last month's decision by an advisory panel to the U.S. Food and Drug Administration to &quot;ease restrictions&quot; on the sale of Avandia (rosiglitazone), a much maligned diabetes drug, is a case in point. Avandia was found to increase the risk of heart failure and death. But a re-evaluation has led to a softening of stand. Tobacco being a leading cause of bladder cancer is well known. With millions of tobacco users in the country, only well-designed studies can help in pinpointing the pioglitazone-cancer causative association. The cheap and effective drug has been in the market for about a decade and many thousands have been using it for a long duration and at lower dosages than in the West. The government may have the power to act but Indian diabetics have the right to an informed decision. </p>               </font>
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While a few large studies conducted elsewhere have shown increased risk, a few others have not. The fact that three countries have placed varying restrictions on the drug&#039;s use should have prompted Indian officials to conduct large-scale studies. Even now, there are overwhelming compulsions to immediately undertake such studies to know the actual risk. Any decision to continue with, remove or rephrase the contents of the boxed warning should be based on those results. Last month&#039;s decision by an advisory panel to the U.S. Food and Drug Administration to &amp;quot;ease restrictions&amp;quot; on the sale of Avandia (rosiglitazone), a much maligned diabetes drug, is a case in point. Avandia was found to increase the risk of heart failure and death. But a re-evaluation has led to a softening of stand. Tobacco being a leading cause of bladder cancer is well known. With millions of tobacco users in the country, only well-designed studies can help in pinpointing the pioglitazone-cancer causative association. The cheap and effective drug has been in the market for about a decade and many thousands have been using it for a long duration and at lower dosages than in the West. The government may have the power to act but Indian diabetics have the right to an informed decision. 
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-The Hindu



That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June..."/>
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                <strong>Let the science decide</strong></h1>
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                <div align="justify">-The Hindu</div><p align="justify"><br />That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June 18 nor its revocation a month later with a requirement that the medicine be sold with a boxed warning highlighting the adverse side-effect of bladder cancer was based on any scientific evidence from India. The excessive haste and utter secrecy in which the drug was banned raises serious concerns about the decision-making process. It is shocking that eight &lsquo;cases' of bladder cancer in patients who are on pioglitazone was the only &lsquo;data' the ministry relied on to ban a drug that has been used by a sizeable number of diabetics for about a decade. As if the statistically insignificant number of &lsquo;cases' it relied on to take a decision was not shocking enough, it relied on &lsquo;data' that never came under scientific scrutiny. This best portrays how cavalier policymakers can be. If the basis on which the drug was banned is baffling, the grounds on which the ban was revoked with a box warning is puzzling. After all, an Indian study of 958 patients who are on pioglitazone but with no cancer after two years of treatment is the only scientifically valid data currently available. It is also well known that Indians have a different genetic profile from Caucasians and very contrasting characteristics, which make them more susceptible to diabetes.</p><p align="justify">While a few large studies conducted elsewhere have shown increased risk, a few others have not. The fact that three countries have placed varying restrictions on the drug's use should have prompted Indian officials to conduct large-scale studies. Even now, there are overwhelming compulsions to immediately undertake such studies to know the actual risk. Any decision to continue with, remove or rephrase the contents of the boxed warning should be based on those results. Last month's decision by an advisory panel to the U.S. Food and Drug Administration to &quot;ease restrictions&quot; on the sale of Avandia (rosiglitazone), a much maligned diabetes drug, is a case in point. Avandia was found to increase the risk of heart failure and death. But a re-evaluation has led to a softening of stand. Tobacco being a leading cause of bladder cancer is well known. With millions of tobacco users in the country, only well-designed studies can help in pinpointing the pioglitazone-cancer causative association. The cheap and effective drug has been in the market for about a decade and many thousands have been using it for a long duration and at lower dosages than in the West. The government may have the power to act but Indian diabetics have the right to an informed decision. </p>               </font>
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Let the science decide

-The Hindu That the Union Health Ministry takes critical decisions affecting a large number of people without any scientific basis does not portend well for public health in India. Neither the ban imposed on the oral anti-diabetes drug pioglitazone on June 18 nor its revocation a month later with a requirement that the medicine be sold with a boxed warning highlighting the adverse side-effect of bladder cancer was based on any scientific evidence from India. The excessive haste and utter secrecy in which the drug was banned raises serious concerns about the decision-making process. It is shocking that eight ‘cases' of bladder cancer in patients who are on pioglitazone was the only ‘data' the ministry relied on to ban a drug that has been used by a sizeable number of diabetics for about a decade. As if the statistically insignificant number of ‘cases' it relied on to take a decision was not shocking enough, it relied on ‘data' that never came under scientific scrutiny. This best portrays how cavalier policymakers can be. If the basis on which the drug was banned is baffling, the grounds on which the ban was revoked with a box warning is puzzling. After all, an Indian study of 958 patients who are on pioglitazone but with no cancer after two years of treatment is the only scientifically valid data currently available. It is also well known that Indians have a different genetic profile from Caucasians and very contrasting characteristics, which make them more susceptible to diabetes. While a few large studies conducted elsewhere have shown increased risk, a few others have not. The fact that three countries have placed varying restrictions on the drug's use should have prompted Indian officials to conduct large-scale studies. Even now, there are overwhelming compulsions to immediately undertake such studies to know the actual risk. Any decision to continue with, remove or rephrase the contents of the boxed warning should be based on those results. Last month's decision by an advisory panel to the U.S. Food and Drug Administration to "ease restrictions" on the sale of Avandia (rosiglitazone), a much maligned diabetes drug, is a case in point. Avandia was found to increase the risk of heart failure and death. But a re-evaluation has led to a softening of stand. Tobacco being a leading cause of bladder cancer is well known. With millions of tobacco users in the country, only well-designed studies can help in pinpointing the pioglitazone-cancer causative association. The cheap and effective drug has been in the market for about a decade and many thousands have been using it for a long duration and at lower dosages than in the West. The government may have the power to act but Indian diabetics have the right to an informed decision.