Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 73
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::printArticle() - APP/Controller/ArtileDetailController.php, line 73
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 610
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 162
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 74
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::printArticle() - APP/Controller/ArtileDetailController.php, line 74
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 610
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 162
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\AssetMiddleware::__invoke() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 88
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Warning (512): Unable to emit headers. Headers sent in file=/home/brlfuser/public_html/vendor/cakephp/cakephp/src/Error/Debugger.php line=853 [CORE/src/Http/ResponseEmitter.php, line 48]
Code Context
            if (Configure::read('debug')) {

                trigger_error($message, E_USER_WARNING);

            } else {
$response = object(Cake\Http\Response) {

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</span></span></code>
<span class="code-highlight"><code><span style="color: #000000">&nbsp;&nbsp;&nbsp;&nbsp;&lt;link&nbsp;rel="canonical"&nbsp;href="<span style="color: #0000BB">&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">Configure</span><span style="color: #007700">::</span><span style="color: #0000BB">read</span><span style="color: #007700">(</span><span style="color: #DD0000">'SITE_URL'</span><span style="color: #007700">);&nbsp;</span><span style="color: #0000BB">?&gt;&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">$urlPrefix</span><span style="color: #007700">;</span><span style="color: #0000BB">?&gt;&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">$article_current</span><span style="color: #007700">-&gt;</span><span style="color: #0000BB">category</span><span style="color: #007700">-&gt;</span><span style="color: #0000BB">slug</span><span style="color: #007700">;&nbsp;</span><span style="color: #0000BB">?&gt;</span>/<span style="color: #0000BB">&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">$article_current</span><span style="color: #007700">-&gt;</span><span style="color: #0000BB">seo_url</span><span style="color: #007700">;&nbsp;</span><span style="color: #0000BB">?&gt;</span>.html"/&gt;
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-The Times of India&lt;br /&gt;
&lt;br /&gt;
&lt;em&gt;NEW DELHI: &lt;/em&gt;The mystery behind the outbreak of an unexplained neurological illness in Bihar&#039;s Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.&lt;br /&gt;
&lt;br /&gt;
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. &lt;br /&gt;
&lt;br /&gt;
According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.&lt;br /&gt;
&lt;br /&gt;
In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. &lt;br /&gt;
&lt;br /&gt;
Please &lt;a href=&quot;http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms&quot;&gt;click here&lt;/a&gt; to read more. 
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&lt;em&gt;NEW DELHI: &lt;/em&gt;The mystery behind the outbreak of an unexplained neurological illness in Bihar&#039;s Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.&lt;br /&gt;
&lt;br /&gt;
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. &lt;br /&gt;
&lt;br /&gt;
According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.&lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
Please &lt;a href=&quot;http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms&quot;&gt;click here&lt;/a&gt; to read more. 
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NEW DELHI: The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint..."/>
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                <div align="justify">-The Times of India<br /><br /><em>NEW DELHI: </em>The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.<br /><br />Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. <br /><br />According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.<br /><br />In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. <br /><br />Please <a href="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms" title="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms">click here</a> to read more. </div><div align="justify">&nbsp;</div>               </font>
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    <link rel="canonical" href="https://im4change.in/<pre class="cake-error"><a href="javascript:void(0);" onclick="document.getElementById('cakeErr681eaaf037c9b-trace').style.display = (document.getElementById('cakeErr681eaaf037c9b-trace').style.display == 'none' ? '' : 'none');"><b>Notice</b> (8)</a>: Undefined variable: urlPrefix [<b>APP/Template/Layout/printlayout.ctp</b>, line <b>8</b>]<div id="cakeErr681eaaf037c9b-trace" class="cake-stack-trace" style="display: none;"><a href="javascript:void(0);" onclick="document.getElementById('cakeErr681eaaf037c9b-code').style.display = (document.getElementById('cakeErr681eaaf037c9b-code').style.display == 'none' ? '' : 'none')">Code</a> <a href="javascript:void(0);" onclick="document.getElementById('cakeErr681eaaf037c9b-context').style.display = (document.getElementById('cakeErr681eaaf037c9b-context').style.display == 'none' ? '' : 'none')">Context</a><pre id="cakeErr681eaaf037c9b-code" class="cake-code-dump" style="display: none;"><code><span style="color: #000000"><span style="color: #0000BB"></span><span style="color: #007700">&lt;</span><span style="color: #0000BB">head</span><span style="color: #007700">&gt;
</span></span></code>
<span class="code-highlight"><code><span style="color: #000000">&nbsp;&nbsp;&nbsp;&nbsp;&lt;link&nbsp;rel="canonical"&nbsp;href="<span style="color: #0000BB">&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">Configure</span><span style="color: #007700">::</span><span style="color: #0000BB">read</span><span style="color: #007700">(</span><span style="color: #DD0000">'SITE_URL'</span><span style="color: #007700">);&nbsp;</span><span style="color: #0000BB">?&gt;&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">$urlPrefix</span><span style="color: #007700">;</span><span style="color: #0000BB">?&gt;&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">$article_current</span><span style="color: #007700">-&gt;</span><span style="color: #0000BB">category</span><span style="color: #007700">-&gt;</span><span style="color: #0000BB">slug</span><span style="color: #007700">;&nbsp;</span><span style="color: #0000BB">?&gt;</span>/<span style="color: #0000BB">&lt;?php&nbsp;</span><span style="color: #007700">echo&nbsp;</span><span style="color: #0000BB">$article_current</span><span style="color: #007700">-&gt;</span><span style="color: #0000BB">seo_url</span><span style="color: #007700">;&nbsp;</span><span style="color: #0000BB">?&gt;</span>.html"/&gt;
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-The Times of India&lt;br /&gt;
&lt;br /&gt;
&lt;em&gt;NEW DELHI: &lt;/em&gt;The mystery behind the outbreak of an unexplained neurological illness in Bihar&#039;s Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.&lt;br /&gt;
&lt;br /&gt;
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. &lt;br /&gt;
&lt;br /&gt;
According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.&lt;br /&gt;
&lt;br /&gt;
In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. &lt;br /&gt;
&lt;br /&gt;
Please &lt;a href=&quot;http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms&quot;&gt;click here&lt;/a&gt; to read more. 
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&lt;br /&gt;
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. &lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
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&lt;br /&gt;
Please &lt;a href=&quot;http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms&quot;&gt;click here&lt;/a&gt; to read more. 
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Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 126
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
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NEW DELHI: The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint..."/>
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                <strong>Litchi behind mystery deaths in Bihar: US-India study -Durgesh Nandan Jha</strong></h1>
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                <div align="justify">-The Times of India<br /><br /><em>NEW DELHI: </em>The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.<br /><br />Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. <br /><br />According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.<br /><br />In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. <br /><br />Please <a href="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms" title="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms">click here</a> to read more. </div><div align="justify">&nbsp;</div>               </font>
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-The Times of India&lt;br /&gt;
&lt;br /&gt;
&lt;em&gt;NEW DELHI: &lt;/em&gt;The mystery behind the outbreak of an unexplained neurological illness in Bihar&#039;s Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.&lt;br /&gt;
&lt;br /&gt;
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. &lt;br /&gt;
&lt;br /&gt;
According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.&lt;br /&gt;
&lt;br /&gt;
In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. &lt;br /&gt;
&lt;br /&gt;
Please &lt;a href=&quot;http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms&quot;&gt;click here&lt;/a&gt; to read more. 
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&lt;br /&gt;
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. &lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
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NEW DELHI: The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint..."/>
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                <strong>Litchi behind mystery deaths in Bihar: US-India study -Durgesh Nandan Jha</strong></h1>
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                <div align="justify">-The Times of India<br /><br /><em>NEW DELHI: </em>The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.<br /><br />Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. <br /><br />According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.<br /><br />In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. <br /><br />Please <a href="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms" title="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms">click here</a> to read more. </div><div align="justify">&nbsp;</div>               </font>
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-The Times of India<br />
<br />
<em>NEW DELHI: </em>The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.<br />
<br />
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. <br />
<br />
According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.<br />
<br />
In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. <br />
<br />
Please <a href="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms">click here</a> to read more. 
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<em>NEW DELHI: </em>The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death.<br />
<br />
Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. <br />
<br />
According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything.<br />
<br />
In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. <br />
<br />
Please <a href="http://timesofindia.indiatimes.com/india/litchi-behind-mystery-deaths-in-bihar-us-india-study/articleshow/56902854.cms">click here</a> to read more. 
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Litchi behind mystery deaths in Bihar: US-India study -Durgesh Nandan Jha

-The Times of India NEW DELHI: The mystery behind the outbreak of an unexplained neurological illness in Bihar's Muzaffarpur, which had claimed nearly 100 lives each year till 2014, has been solved. Scientists from the US and India, after a joint investigation, have concluded that consuming litchi --a tropical fruit Muzaffarpur is famous for- on an empty stomach triggers the illness and death. Seasonal outbreak of the mysterious illness, characterised by acute seizures and changed mental status, has been plaguing Muzaffarpur for nearly two decades. Some similar cases have been reported from Malda in West Bengal. According to researchers, skipping an evening meal results in night-time hypoglycaemia, or low-blood sugar, particularly in children with limited reserve of glycogen -glucose stored in liver and muscles. This triggers oxidation of fatty acids for energy production and generation of glucose. However, naturally-occurring toxins that are found in litchis --hypoglycin A and methylenecyclopropylglycine (MPCG) - disrupt the fatty acid metabolism, leading to acutely low levels of blood sugar. This further affects brain function, leading to acute seizures and stroke. The reserach findings have been published in the latest issue of medical journal The Lancet. For years, many theories were proposed for the seasonal outbreak, including the possibility of pesticide exposure and infectious encephalitis, but no one could confirm anything. In 2013, the National Centre for Disease Control (NCDC) in India and US Center for Disease Control initiated a joint investigation into the matter. The hospital-based surveillance involved laboratory investigations to assess potential infectious and non-infectious causes in 390 children less than 15 years old, who were admitted to Shri Krishna Medical College hospital and Krishnadevi Deviprasad Kejriwal maternity hospital -the chief referral medical centres in Muzaffarpur with sudden neurological illness. Of them, 122 (31%) died. Please click here to read more.