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Price cut on TB drug to expand access

-The Hindu Business Line

Agreement between Viatris, MedAccess and TBA to slash cost by 34 per cent on pretomanid

A new agreement among drugmaker Viatris, MedAccess, and TB Alliance looks to reduce the price of pretomanid, a drug used to treat multidrug-resistant tuberculosis, by 34 per cent.

The agreement will help expand access to this critical new treatment in more than 140 countries, including those with the highest TB burden, said a joint note from the organisations.

Pretomanid (Pa) is used in combination with bedaquiline (B), linezolid (L), and sometimes moxifloxacin (M) to form BPaL and BPaLM – a six-month, all-oral treatment regimen, found to be effective at curing about 90 per cent of multidrug-resistant TB (MDR-TB) patients.

Treatment previously recommended has been limited, expensive, toxic, and lengthy – requiring patients to take more than 20 pills per day for 9-20 months. However, with the new WHO guidance on TB treatment, almost all drug-resistant TB patients will now be eligible for the shorter BPaL/BPaLM regimens, the note said.

In July 2020, the Drugs Controller General of India (DCGI) had approved the TB drug pretomanid (developed specifically for certain drug-resistant forms of the disease) for conditional access under the National Tuberculosis Elimination Program (NTEP), making India the second country in the world to provide regulatory approval for this product.

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