Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 73
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::printArticle() - APP/Controller/ArtileDetailController.php, line 73
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Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 74
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::printArticle() - APP/Controller/ArtileDetailController.php, line 74
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 610
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 162
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\AssetMiddleware::__invoke() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 88
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Warning (512): Unable to emit headers. Headers sent in file=/home/brlfuser/public_html/vendor/cakephp/cakephp/src/Error/Debugger.php line=853 [CORE/src/Http/ResponseEmitter.php, line 48]
Code Context
            if (Configure::read('debug')) {

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    <link rel="canonical" href="https://im4change.in/<pre class="cake-error"><a href="javascript:void(0);" onclick="document.getElementById('cakeErr6804f3795ec7d-trace').style.display = (document.getElementById('cakeErr6804f3795ec7d-trace').style.display == 'none' ? '' : 'none');"><b>Notice</b> (8)</a>: Undefined variable: urlPrefix [<b>APP/Template/Layout/printlayout.ctp</b>, line <b>8</b>]<div id="cakeErr6804f3795ec7d-trace" class="cake-stack-trace" style="display: none;"><a href="javascript:void(0);" onclick="document.getElementById('cakeErr6804f3795ec7d-code').style.display = (document.getElementById('cakeErr6804f3795ec7d-code').style.display == 'none' ? '' : 'none')">Code</a> <a href="javascript:void(0);" onclick="document.getElementById('cakeErr6804f3795ec7d-context').style.display = (document.getElementById('cakeErr6804f3795ec7d-context').style.display == 'none' ? '' : 'none')">Context</a><pre id="cakeErr6804f3795ec7d-code" class="cake-code-dump" style="display: none;"><code><span style="color: #000000"><span style="color: #0000BB"></span><span style="color: #007700">&lt;</span><span style="color: #0000BB">head</span><span style="color: #007700">&gt;
</span></span></code>
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</span></span></code></pre><pre id="cakeErr6804f3795ec7d-context" class="cake-context" style="display: none;">$viewFile = &#039;/home/brlfuser/public_html/src/Template/Layout/printlayout.ctp&#039;
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-Express News Service
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
&lt;br /&gt;
The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;
&lt;br /&gt;
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;
&lt;br /&gt;
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
&lt;br /&gt;
&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;
&lt;br /&gt;
&amp;ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&amp;rdquo; she added.
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-Express News Service



The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil...&#039;,
	&#039;disp&#039; =&gt; &#039;&lt;p align=&quot;justify&quot;&gt;-Express News Service&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;&lt;br /&gt;Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;&lt;br /&gt;According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;&lt;br /&gt;Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;&lt;br /&gt;Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;&lt;br /&gt;&amp;ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&amp;rdquo; she added.&lt;/p&gt;&#039;,
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&lt;/p&gt;
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&lt;br /&gt;
The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;
&lt;br /&gt;
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;
&lt;br /&gt;
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
&lt;br /&gt;
&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;
&lt;br /&gt;
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-Express News Service



The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil..."/>
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                <strong>Researchers find new molecule to fight TB</strong></h1>
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                <p align="justify">-Express News Service</p><p align="justify"><br />The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.</p><p align="justify">Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.<br /><br />Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&rdquo;<br /><br />These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&rsquo;s side effects would be minimal.<br /><br />According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &ldquo;This will help in preventing resistance from forming,&rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.<br /><br />Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &ldquo;This is a breakthrough,&rdquo; she says, &ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&rdquo;<br /><br />The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.</p><p align="justify"><br />&ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.<br /><br />Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&rdquo; she said.<br /><br />&ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&rdquo; she added.</p>               </font>
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-Express News Service
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&lt;br /&gt;
The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;
&lt;br /&gt;
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;
&lt;br /&gt;
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;
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&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;
&lt;br /&gt;
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Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil...&#039;,
	&#039;disp&#039; =&gt; &#039;&lt;p align=&quot;justify&quot;&gt;-Express News Service&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;&lt;br /&gt;Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;&lt;br /&gt;According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;&lt;br /&gt;Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;&lt;br /&gt;Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;&lt;br /&gt;&amp;ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&amp;rdquo; she added.&lt;/p&gt;&#039;,
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The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
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&lt;br /&gt;
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;
&lt;br /&gt;
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;
&lt;br /&gt;
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
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&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
&lt;br /&gt;
&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;
&lt;br /&gt;
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The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil...&#039;
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-Express News Service



The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil..."/>
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                <strong>Researchers find new molecule to fight TB</strong></h1>
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                <p align="justify">-Express News Service</p><p align="justify"><br />The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.</p><p align="justify">Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.<br /><br />Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&rdquo;<br /><br />These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&rsquo;s side effects would be minimal.<br /><br />According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &ldquo;This will help in preventing resistance from forming,&rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.<br /><br />Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &ldquo;This is a breakthrough,&rdquo; she says, &ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&rdquo;<br /><br />The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.</p><p align="justify"><br />&ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.<br /><br />Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&rdquo; she said.<br /><br />&ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&rdquo; she added.</p>               </font>
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-Express News Service
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&lt;br /&gt;
The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;
&lt;br /&gt;
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;
&lt;br /&gt;
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;
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&lt;br /&gt;
Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;
&lt;br /&gt;
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-Express News Service



The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil...&#039;,
	&#039;disp&#039; =&gt; &#039;&lt;p align=&quot;justify&quot;&gt;-Express News Service&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;&lt;br /&gt;Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;&lt;br /&gt;According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;&lt;br /&gt;Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;&lt;br /&gt;Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;&lt;br /&gt;&amp;ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&amp;rdquo; she added.&lt;/p&gt;&#039;,
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&lt;p align=&quot;justify&quot;&gt;
&lt;br /&gt;
The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;
&lt;br /&gt;
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;
&lt;br /&gt;
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;
&lt;br /&gt;
The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.
&lt;/p&gt;
&lt;p align=&quot;justify&quot;&gt;
&lt;br /&gt;
&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;
&lt;br /&gt;
Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;
&lt;br /&gt;
&amp;ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&amp;rdquo; she added.
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-Express News Service



The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil...&#039;
$disp = &#039;&lt;p align=&quot;justify&quot;&gt;-Express News Service&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.&lt;br /&gt;&lt;br /&gt;Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &amp;ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&amp;rsquo;s side effects would be minimal.&lt;br /&gt;&lt;br /&gt;According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &amp;ldquo;This will help in preventing resistance from forming,&amp;rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.&lt;br /&gt;&lt;br /&gt;Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &amp;mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &amp;ldquo;This is a breakthrough,&amp;rdquo; she says, &amp;ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&amp;rdquo;&lt;br /&gt;&lt;br /&gt;The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.&lt;/p&gt;&lt;p align=&quot;justify&quot;&gt;&lt;br /&gt;&amp;ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&amp;rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.&lt;br /&gt;&lt;br /&gt;Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &amp;ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&amp;rdquo; she said.&lt;br /&gt;&lt;br /&gt;&amp;ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&amp;rdquo; she added.&lt;/p&gt;&#039;
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The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil..."/>
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                <strong>Researchers find new molecule to fight TB</strong></h1>
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                <p align="justify">-Express News Service</p><p align="justify"><br />The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.</p><p align="justify">Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.<br /><br />Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&rdquo;<br /><br />These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&rsquo;s side effects would be minimal.<br /><br />According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &ldquo;This will help in preventing resistance from forming,&rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.<br /><br />Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &ldquo;This is a breakthrough,&rdquo; she says, &ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&rdquo;<br /><br />The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.</p><p align="justify"><br />&ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.<br /><br />Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&rdquo; she said.<br /><br />&ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&rdquo; she added.</p>               </font>
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-Express News Service
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<p align="justify">
<br />
The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
</p>
<p align="justify">
Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.<br />
<br />
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&rdquo;<br />
<br />
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&rsquo;s side effects would be minimal.<br />
<br />
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &ldquo;This will help in preventing resistance from forming,&rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.<br />
<br />
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &ldquo;This is a breakthrough,&rdquo; she says, &ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&rdquo;<br />
<br />
The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.
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<br />
&ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.<br />
<br />
Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&rdquo; she said.<br />
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&ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&rdquo; she added.
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-Express News Service
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<br />
The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.
</p>
<p align="justify">
Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.<br />
<br />
Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&rdquo;<br />
<br />
These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&rsquo;s side effects would be minimal.<br />
<br />
According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &ldquo;This will help in preventing resistance from forming,&rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.<br />
<br />
Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &ldquo;This is a breakthrough,&rdquo; she says, &ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&rdquo;<br />
<br />
The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.
</p>
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<br />
&ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.<br />
<br />
Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&rdquo; she said.<br />
<br />
&ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&rdquo; she added.
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$metaTitle = 'LATEST NEWS UPDATES | Researchers find new molecule to fight TB'
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-Express News Service



The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.


Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil...'
$disp = '<p align="justify">-Express News Service</p><p align="justify"><br />The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV.</p><p align="justify">Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008.<br /><br />Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. &ldquo;This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.&rdquo;<br /><br />These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it&rsquo;s side effects would be minimal.<br /><br />According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. &ldquo;This will help in preventing resistance from forming,&rdquo; he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult.<br /><br />Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India &mdash; HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. &ldquo;This is a breakthrough,&rdquo; she says, &ldquo;Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.&rdquo;<br /><br />The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines.</p><p align="justify"><br />&ldquo;The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.&rdquo; Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages.<br /><br />Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. &ldquo;TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,&rdquo; she said.<br /><br />&ldquo;Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,&rdquo; she added.</p>'
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Researchers find new molecule to fight TB

-Express News Service The Tuberculosis Research Centre (TRC) in the city, on Wednesday, announced that it had isolated a molecule that fights both tuberculosis and some strains of HIV. Researchers isolated the molecule from a marine microorganism Streptomyces sp found in soil collected near coral reefs off the Rameshwaram coast. They found that the molecule was effective against Mycobacterium tuberculosis, the bacteria that causes most forms of TB. The molecule also acts against the B and C strains of HIV, that are the most common. The TRC collaborated with Periyar University and IIT-Madras on the research which first began in 2008. Dr Vanaja Kumar, the principal investigator, and head of department of Bacteriology, TRC, said the compound had been named Transitmycin. “This one was selected as it was from an extreme environment which man is not part of, and therefore cannot be immune to. It is also pigmented and has a simple structure with a small molecule.” These factors meant the molecule could be easily absorbed by the human body and if developed into a drug, it’s side effects would be minimal. According to Dr Mukesh Doble, of the department of Biotechnology, IIT- Madras, a co-investigator on the project, as Transitmycin was a simple compound, its structure could be changed every few years. “This will help in preventing resistance from forming,” he said pointing out that the bacteria causing TB had developed a multidrug resistance making the effective treatment of patients more difficult. Dr Luke Elizabeth Hanna, scientist, TRC had also started testing the new molecule on the most common HIV strain in India — HIV C. Over the last two weeks, she found that it the molecule had an inhibitory action on the virus. “This is a breakthrough,” she says, “Those with HIV are very prone to TB. Some drugs for TB cannot be given at the same time as the treatment for HIV. When developed, this would have the potential to be a single cure for both diseases.” The next stage of research would involve pre-clinical trials and animal and human testing. Dr Vanaja said that the molecule had been tested on human cell lines. “The toxicity is within permissible levels. We have filed a patent for intellectual property rights and have requested funding.” Dr Doble estimated that a minimum of `200 to `300 crore would be required for the next stages. Dr Vanaja added that a drug made with the molecule would not be ready for the next seven to 10 years. “TB is a disease which develops slowly in both animals and humans. So the clinical trial will take longer,” she said. “Even if we find a more effective cure, we will continue research on Transitmycin. The world could do with many different medicines against TB,” she added.