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<p style="text-align:justify"><em>Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors</em></p>
<p style="text-align:justify">The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the proportion of a population already infected, as evidenced by antibody positivity. When applied on a national scale, a random sample of the entire population is tested. Then, the data are extrapolated to the whole population.</p>
<p style="text-align:justify">‘Random’, according to the dictionary, means something without a deliberate order. In biostatistics, it means each individual has an equal probability of getting selected. Statisticians stratify the population and select a random sample from all strata so that the prevalence figure obtained is representative of the whole population. The result of random sample serosurveys can be confidently extrapolated to obtain national-level prevalence of antibodies.</p>
<p style="text-align:justify"><em>What antibody tests say</em></p>
<p style="text-align:justify">Unfortunately there are problems with the antibody tests. Antibodies are the footprints of the host’s response to virus infection. Their presence in the blood-serum confirms past infection. However, test results for antibodies throw up surprises. Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors.</p>
<p style="text-align:justify">The virus carries several antigens, both on the surface and internally. The body responds to all of them. Four antigens selected to detect antibodies are spike protein (S1, S2), receptor-binding domain (RBD) and nucleocapsid (N). An antibody against each antigen has its own time of appearance, duration in blood and rate of decay over time. Moreover, detection of antibodies does not correlate well with the protective virus-neutralising function of immunity. Testing for virus-neutralising antibodies is not an option, since handling the virus is risky for lab personnel. It is prohibited in clinical labs and restricted to selected research labs.</p>
<p style="text-align:justify">Please <a href="https://www.thehindu.com/opinion/op-ed/serosurveys-underestimate-building-of-herd-immunity/article33005833.ece?homepage=true">click here</a> to read more.</p>
<p style="text-align:justify"> </p>
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LATEST NEWS UPDATES | Serosurveys underestimate building of herd immunity -MS Seshadri & T Jacob John </title>
<meta name="description" content="-The Hindu
Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the..."/>
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<meta property="og:description" content="-The Hindu
Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the..." />
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<br><small>November 3, 2020</small>
<p style="padding-top: 6px;">-The Hindu
Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the proportion of a population already...</p>
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<br><small>November 2, 2020</small>
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Rajasthan has amended The Farmers' Produce Trade and Commerce (promotion and facilitation) Act, 2020 to restore what it calls 'the safeguards for the farmers of the state' as under state's APMC Act
The Congress-ruled states’ plan to nullify the three central laws on agricultural markets...</p>
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<br><small>November 2, 2020</small>
<p style="padding-top: 6px;">-NetworkIdeas.org
The International Labour Organization (ILO) has for some months been bringing out a report that monitors the impact of the pandemic on the world economy, especially the labour-hours lost because of the lockdown and their ramifications. The statistics it provides are not compilations of official...</p>
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<br><small>November 2, 2020</small>
<p style="padding-top: 6px;">-The Hindu
20% of people demanding work have been denied; even higher on ground, say workers.
Having run through 74% of its labour budget under the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) at the halfway point of the year, and expecting the demand to go...</p>
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<br><small>November 2, 2020</small>
<p style="padding-top: 6px;">-Financial Express
The current guidelines may not inspire confidence among farmers on entering into collective enterprises.
Prime minister Narendra Modi, in his address commemorating 75 years of the UN’s FAO, reiterated India’s commitment to enhance its farmers’ income. He also reiterated the resolve to create 10,000 additional...</p>
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LATEST NEWS UPDATES | Serosurveys underestimate building of herd immunity -MS Seshadri & T Jacob John </title>
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Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the..."/>
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Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the..." />
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<br><small>November 3, 2020</small>
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Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the proportion of a population already...</p>
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<br><small>November 2, 2020</small>
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Rajasthan has amended The Farmers' Produce Trade and Commerce (promotion and facilitation) Act, 2020 to restore what it calls 'the safeguards for the farmers of the state' as under state's APMC Act
The Congress-ruled states’ plan to nullify the three central laws on agricultural markets...</p>
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<br><small>November 2, 2020</small>
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The International Labour Organization (ILO) has for some months been bringing out a report that monitors the impact of the pandemic on the world economy, especially the labour-hours lost because of the lockdown and their ramifications. The statistics it provides are not compilations of official...</p>
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<br><small>November 2, 2020</small>
<p style="padding-top: 6px;">-The Hindu
20% of people demanding work have been denied; even higher on ground, say workers.
Having run through 74% of its labour budget under the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) at the halfway point of the year, and expecting the demand to go...</p>
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<br><small>November 2, 2020</small>
<p style="padding-top: 6px;">-Financial Express
The current guidelines may not inspire confidence among farmers on entering into collective enterprises.
Prime minister Narendra Modi, in his address commemorating 75 years of the UN’s FAO, reiterated India’s commitment to enhance its farmers’ income. He also reiterated the resolve to create 10,000 additional...</p>
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LATEST NEWS UPDATES | Serosurveys underestimate building of herd immunity -MS Seshadri & T Jacob John </title>
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Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the..."/>
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<br><small>November 3, 2020</small>
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Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the proportion of a population already...</p>
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<br><small>November 2, 2020</small>
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Rajasthan has amended The Farmers' Produce Trade and Commerce (promotion and facilitation) Act, 2020 to restore what it calls 'the safeguards for the farmers of the state' as under state's APMC Act
The Congress-ruled states’ plan to nullify the three central laws on agricultural markets...</p>
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The International Labour Organization (ILO) has for some months been bringing out a report that monitors the impact of the pandemic on the world economy, especially the labour-hours lost because of the lockdown and their ramifications. The statistics it provides are not compilations of official...</p>
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<br><small>November 2, 2020</small>
<p style="padding-top: 6px;">-The Hindu
20% of people demanding work have been denied; even higher on ground, say workers.
Having run through 74% of its labour budget under the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) at the halfway point of the year, and expecting the demand to go...</p>
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<br><small>November 2, 2020</small>
<p style="padding-top: 6px;">-Financial Express
The current guidelines may not inspire confidence among farmers on entering into collective enterprises.
Prime minister Narendra Modi, in his address commemorating 75 years of the UN’s FAO, reiterated India’s commitment to enhance its farmers’ income. He also reiterated the resolve to create 10,000 additional...</p>
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LATEST NEWS UPDATES | Serosurveys underestimate building of herd immunity -MS Seshadri & T Jacob John
-The Hindu
Antibody prevalence data derived from serosurveys must be interpreted with caution and correction factors
The theory behind population-based serological surveys (seroprevalence surveys or serosurveys) to detect the prevalence of antibodies against COVID-19 is robust. Their purpose is to measure the proportion of a population already...
-Business Standard
Rajasthan has amended The Farmers' Produce Trade and Commerce (promotion and facilitation) Act, 2020 to restore what it calls 'the safeguards for the farmers of the state' as under state's APMC Act
The Congress-ruled states’ plan to nullify the three central laws on agricultural markets...
-NetworkIdeas.org
The International Labour Organization (ILO) has for some months been bringing out a report that monitors the impact of the pandemic on the world economy, especially the labour-hours lost because of the lockdown and their ramifications. The statistics it provides are not compilations of official...
-The Hindu
20% of people demanding work have been denied; even higher on ground, say workers.
Having run through 74% of its labour budget under the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) at the halfway point of the year, and expecting the demand to go...
-Financial Express
The current guidelines may not inspire confidence among farmers on entering into collective enterprises.
Prime minister Narendra Modi, in his address commemorating 75 years of the UN’s FAO, reiterated India’s commitment to enhance its farmers’ income. He also reiterated the resolve to create 10,000 additional...
