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LATEST NEWS UPDATES | A big step forward-CP Chandrasekhar </title>
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That this is the first time a compulsory licence has been granted in India is in itself important.
INDIA'S long struggle to ensure access to affordable medicines for its people recently took a positive and interesting turn. In early March, just..."/>
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That this is the first time a compulsory licence has been granted in India is in itself important.
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<h1 class="cat-box-title">A big step forward-CP Chandrasekhar</h1>
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Published on</span><span class="text-date"> Apr 20, 2012</span>
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<br /><div align="justify"><em>That this is the first time a compulsory licence has been granted in India is in itself important.<br /></em><br />INDIA'S long struggle to ensure access to affordable medicines for its people recently took a positive and interesting turn. In early March, just before he demitted office, Controller General of Patents P.H. Kurian passed an order on an application filed by Natco Pharma, headquartered in Hyderabad, requesting a licence to produce an anti-cancer drug (sorafenib tosylate), the patent for which is held by the German pharmaceuticals and chemicals giant Bayer. It produces and markets the drug under the brand name Nexavar, which is used in the treatment of patients diagnosed as being in the advanced stages of affliction with liver or kidney cancer. Having failed to obtain a voluntary licence for manufacture from Bayer, Natco had filed an application under Section 84 of the Indian Patents Act, which specifies the conditions under which a “compulsory licence” (CL) may be issued to a producer other than the patentee. Compulsory licensing involves providing an agent, other than the holder of the patent for a product or process, permission to produce or market that product without the consent of the patent holder.<br /><br />Before 2005, when India amended its Patents Act to recognise product patents, Natco or any other Indian pharmaceutical company would not have needed such permission. All it needed to do was demonstrate that it had access to a process technology different from that used by Bayer to produce sorafenib. This encouraged the growth of an industry producing a large number of on-patent (and off-patent) drugs and marketing them at prices much lower than those charged by the original patentees. The net result was the well-documented fact that drug prices in India were among the lowest in the world and there was no shortage of essential drugs in the country.<br /><br />However, once India signed into the Uruguay Round Agreement, which included an agreement on Intellectual Property Rights (IPR), India's Patent Act, 1970, had to be amended thrice, in 1999, 2002 and 2005, to bring it in line with the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). These changes not only replaced the chapter on CLs but culminated in the recognition of product patents. Inasmuch as the latter prevented Indian firms from producing a patented product (unless the technology was voluntarily licensed by the patent holder) and gave the patent holder a monopoly right to produce the product, there was a danger that prices of medicines would rule high and attempts to regulate or control them could lead to inadequate availability of medicines.<br /><br />The TRIPS Agreement was to the disadvantage of less-industrialised developing countries like India, which had registered few patents, including in a crucial area like pharmaceuticals. However, the TRIPs Agreement did provide a few windows of opportunity for governments to intervene to rein in prices in support of needy patients in their countries. Crucial among them was the right (subject to conditions) that the agreement granted governments to resort to “compulsory licensing” on grounds such as the public interest, anti-competitive conduct, or need for non-commercial government use. It was that right that the clauses on CL in the revised Patent Act sought to interpret.<br /><br />What constitutes “public interest” is an issue of significance . In principle, the right of the government to resort to compulsory licensing can be invoked when the patent holder does not work the patent or does so in a manner that is inimical to the public interest, leading to “unreasonable prices”, inadequate technological progress, or inability to deal with public health or other emergencies. However, the TRIPSAgreement did require that the patentee should be notified about possible violations and the prospect of issue of a CL and that negotiations should be held with the patentee to resolve the issue if possible.<br /><br />In the case of pharmaceuticals, this right to issue a CL was strengthened under pressure from developing countries and civil society activists in the Doha Ministerial Declaration of 2001. The Declaration on the TRIPS Agreement and Public Health of 2001 affirmed the power of WTO members “to grant compulsory licences and the freedom to determine the grounds upon which such licences are granted” and held that the agreement “can and should be interpreted and implemented in a manner supportive of WTO Members' rights to protect public health and, in particular, to promote access to medicines for all”.<br /><br />In India these flexibilities became a matter for debate before the revision of the Patents Act was legislated to make it TRIPS-compliant, leading to major advances. One of those advances is the stipulation that a CL can be invoked also in instances where not only the patented product is not reasonably priced (say, relative to costs) but also the price is not reasonably affordable. Section 84 of the Indian Patents Act says: “At any time after the expiration of three years from the date of the grant of a patent, any person interested may make an application to the Controller for grant of compulsory licence on patent on any of the following grounds, namely: (a) that the reasonable requirements of the public with respect to the patented invention have not been satisfied, or (b) that the patented invention is not available to the public at a reasonably affordable price, or (c) that the patented invention is not worked in the territory of India.”<br /><br />What was unclear was how the presence or absence of such grounds for action were to be assessed. Remarkably, after India amended its Patents Act to make it TRIPS compliant and recognise product patents, the government had not, until now, exercised the right to compulsory licensing even once, which would have helped clarify matters. This is despite the fact that in a crucial public health-related area such as drugs and pharmaceuticals the transition to the new regime made a considerable difference to both availability and affordability.<br /><br />Being the first in itself makes the Nexavar judgment historic. But there is more to the judgment than its pioneering character. It is the grounds on which the Controller of Patents accepted Natco's application and rejected Bayer's opposition that are also path-breaking. One important ground was the assessment whether reasonable public requirement was being met with regard to the supply of Nexavar through importation. Noting that: (i) over the years, Bayer had imported the drug in volumes that could have treated only a small fraction (a little above 2 per cent) of those who could be credibly assessed as requiring the drug; (ii) that there were years in which no imports were made; and, (iii) that the company was relying only on the import route and not on local production to work the patent, the Controller General concluded that in a physical sense Bayer was not working the patent. It was not meeting the condition that “the reasonable requirements of the public with respect to the patented invention” were being satisfied.<br /><br />He also rejected the argument that these circumstances with respect to supply of Nexavar had to be judged in the context of the fact that Cipla, another domestic generic pharmaceuticals manufacturer, has without licence been marketing sorafenib in India at a price much lower than that charged by Bayer. Bayer has filed an infringement suit against Cipla, which is pending in the courts. In the circumstances, the Controller General argued that this could not be an excuse for Bayer not ensuring adequate supply of Nexavar.<br /><br />A second important conclusion of the Controller is that the failure to meet demand adequately was partly caused by the high price of the product, which made it unaffordable. While Natco's counsel referred to research findings on reasonable estimates of R&D costs and the per capita incomes of the poor in India to argue that the product was unreasonably priced, the judgment itself focussed on the issue of unaffordability. Even when assessing this, the fundamental issue was not the fact that Nexavar was being priced at around Rs.2.8 lakh for a month's dosage of 120 tablets, when Cipla was supplying the drug at Rs.30,000 for a month's treatment, and Natco was promising the same quantum at Rs.8,800 if granted a licence.<br /><br />Rather, starting from the fact that the sale of Nexavar over the previous four years was only equivalent to a fraction of the public's estimated requirement of this life-extending treatment, Controller General Kurian concluded that the drug “was not bought by the public due to only one reason, that is, its price was not reasonably affordable to them”. This is an important precedent, since it lays down a condition for assessing affordability. If enough of a patented drug that is crucial for the public is not being actually consumed, it must reflect the fact that a significant share of patients are not able to afford the drug at the price at which it can be sold. That does warrant invoking the right to issue a CL.<br /><br />Finally, the judgment examined the issue of whether the patent was being fully worked in India, given that it was only being imported and not manufactured in the country. Counsel for Bayer referred to the fact that the phrase “manufactured in India” was dropped from the Patents Act when it was amended in 2002, to argue that local manufacture was not required to establish “working of a patent”.<br /><br />Moreover, Bayer's counsel argued, cost-effective scales of production of the drug were far above India's requirement. This precluded local manufacture, in which quality control was also difficult to ensure. Not accepting this argument but recognising that the Act does not define the phrase “worked in the territory of India”, the judgment turned to international conventions and the fact that the issue of local manufacture though removed from one context when the Indian Patents Act was amended was incorporated in another clause (Section 84(1)(c)).<br /><br />There are three points the judgment makes here. The first is that while importation rather than local manufacture is not a ground for forfeiture of a patent, a country may use the discretionary powers it has when framing patent legislation to make it a ground for invoking the right to compulsory licensing. Second, the understanding of working the patent in the relevant conventions does not imply working the patent on a “commercial scale”. And, finally but most importantly, “mere importation cannot amount to working of a patented innovation”.<br /><br />According to the judgment, “a patentee is obliged to contribute to the transfer and dissemination of the technology, nationally and internationally, so as to balance rights with obligations. A patentee can achieve this by either manufacturing the product in India or by granting a licence to any other person for manufacturing in India.” This conclusion, if sustained, is also a precedent with implications that go far beyond this case and product.<br /><br />On these grounds the Controller of Patents issued an order giving Natco the right to manufacture and sell a generic version of sorafenib tosylate, subject to pricing it at Rs.8,800 for a monthly dose of 120 tablets and the payment of 6 per cent royalty on the net sales to Bayer.<br /><br />As noted earlier, this judgment does mark a whole new phase in India's journey to fashion a patenting regime that would make medicines affordable to the common man. It is bound to be a precedent that will be quoted in a range of other cases and products. This is not because this is the first instance of grant of a CL, which itself is important. The failure to resort to compulsory licensing thus far was not because of lack of global precedent. In fact, developed countries such as Canada, the United Kingdom and Italy and developing countries such as Brazil, Thailand, Malaysia, South Africa and Kenya have resorted to such licensing in the case of drugs and pharmaceuticals. Very clearly, ideology and international pressure had held back the system.<br /><br />Controller General Kurian has initiated the process through which India can free itself of such fears and exercise its legitimate rights and options. The nation owes him much.</div>
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<br><a href="http://www.frontlineonnet.com/stories/20120504290801000.htm" class="re" target="_blank">Frontline, Volume 29, Issue 08, 21 April-04 May, 2012, http://www.frontlineonnet.com/stories/20120504290801000.htm</a><div class="clear"></div>
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LATEST NEWS UPDATES | A big step forward-CP Chandrasekhar </title>
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<h1 class="cat-box-title">A big step forward-CP Chandrasekhar</h1>
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Published on</span><span class="text-date"> Apr 20, 2012</span>
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<br /><div align="justify"><em>That this is the first time a compulsory licence has been granted in India is in itself important.<br /></em><br />INDIA'S long struggle to ensure access to affordable medicines for its people recently took a positive and interesting turn. In early March, just before he demitted office, Controller General of Patents P.H. Kurian passed an order on an application filed by Natco Pharma, headquartered in Hyderabad, requesting a licence to produce an anti-cancer drug (sorafenib tosylate), the patent for which is held by the German pharmaceuticals and chemicals giant Bayer. It produces and markets the drug under the brand name Nexavar, which is used in the treatment of patients diagnosed as being in the advanced stages of affliction with liver or kidney cancer. Having failed to obtain a voluntary licence for manufacture from Bayer, Natco had filed an application under Section 84 of the Indian Patents Act, which specifies the conditions under which a “compulsory licence” (CL) may be issued to a producer other than the patentee. Compulsory licensing involves providing an agent, other than the holder of the patent for a product or process, permission to produce or market that product without the consent of the patent holder.<br /><br />Before 2005, when India amended its Patents Act to recognise product patents, Natco or any other Indian pharmaceutical company would not have needed such permission. All it needed to do was demonstrate that it had access to a process technology different from that used by Bayer to produce sorafenib. This encouraged the growth of an industry producing a large number of on-patent (and off-patent) drugs and marketing them at prices much lower than those charged by the original patentees. The net result was the well-documented fact that drug prices in India were among the lowest in the world and there was no shortage of essential drugs in the country.<br /><br />However, once India signed into the Uruguay Round Agreement, which included an agreement on Intellectual Property Rights (IPR), India's Patent Act, 1970, had to be amended thrice, in 1999, 2002 and 2005, to bring it in line with the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). These changes not only replaced the chapter on CLs but culminated in the recognition of product patents. Inasmuch as the latter prevented Indian firms from producing a patented product (unless the technology was voluntarily licensed by the patent holder) and gave the patent holder a monopoly right to produce the product, there was a danger that prices of medicines would rule high and attempts to regulate or control them could lead to inadequate availability of medicines.<br /><br />The TRIPS Agreement was to the disadvantage of less-industrialised developing countries like India, which had registered few patents, including in a crucial area like pharmaceuticals. However, the TRIPs Agreement did provide a few windows of opportunity for governments to intervene to rein in prices in support of needy patients in their countries. Crucial among them was the right (subject to conditions) that the agreement granted governments to resort to “compulsory licensing” on grounds such as the public interest, anti-competitive conduct, or need for non-commercial government use. It was that right that the clauses on CL in the revised Patent Act sought to interpret.<br /><br />What constitutes “public interest” is an issue of significance . In principle, the right of the government to resort to compulsory licensing can be invoked when the patent holder does not work the patent or does so in a manner that is inimical to the public interest, leading to “unreasonable prices”, inadequate technological progress, or inability to deal with public health or other emergencies. However, the TRIPSAgreement did require that the patentee should be notified about possible violations and the prospect of issue of a CL and that negotiations should be held with the patentee to resolve the issue if possible.<br /><br />In the case of pharmaceuticals, this right to issue a CL was strengthened under pressure from developing countries and civil society activists in the Doha Ministerial Declaration of 2001. The Declaration on the TRIPS Agreement and Public Health of 2001 affirmed the power of WTO members “to grant compulsory licences and the freedom to determine the grounds upon which such licences are granted” and held that the agreement “can and should be interpreted and implemented in a manner supportive of WTO Members' rights to protect public health and, in particular, to promote access to medicines for all”.<br /><br />In India these flexibilities became a matter for debate before the revision of the Patents Act was legislated to make it TRIPS-compliant, leading to major advances. One of those advances is the stipulation that a CL can be invoked also in instances where not only the patented product is not reasonably priced (say, relative to costs) but also the price is not reasonably affordable. Section 84 of the Indian Patents Act says: “At any time after the expiration of three years from the date of the grant of a patent, any person interested may make an application to the Controller for grant of compulsory licence on patent on any of the following grounds, namely: (a) that the reasonable requirements of the public with respect to the patented invention have not been satisfied, or (b) that the patented invention is not available to the public at a reasonably affordable price, or (c) that the patented invention is not worked in the territory of India.”<br /><br />What was unclear was how the presence or absence of such grounds for action were to be assessed. Remarkably, after India amended its Patents Act to make it TRIPS compliant and recognise product patents, the government had not, until now, exercised the right to compulsory licensing even once, which would have helped clarify matters. This is despite the fact that in a crucial public health-related area such as drugs and pharmaceuticals the transition to the new regime made a considerable difference to both availability and affordability.<br /><br />Being the first in itself makes the Nexavar judgment historic. But there is more to the judgment than its pioneering character. It is the grounds on which the Controller of Patents accepted Natco's application and rejected Bayer's opposition that are also path-breaking. One important ground was the assessment whether reasonable public requirement was being met with regard to the supply of Nexavar through importation. Noting that: (i) over the years, Bayer had imported the drug in volumes that could have treated only a small fraction (a little above 2 per cent) of those who could be credibly assessed as requiring the drug; (ii) that there were years in which no imports were made; and, (iii) that the company was relying only on the import route and not on local production to work the patent, the Controller General concluded that in a physical sense Bayer was not working the patent. It was not meeting the condition that “the reasonable requirements of the public with respect to the patented invention” were being satisfied.<br /><br />He also rejected the argument that these circumstances with respect to supply of Nexavar had to be judged in the context of the fact that Cipla, another domestic generic pharmaceuticals manufacturer, has without licence been marketing sorafenib in India at a price much lower than that charged by Bayer. Bayer has filed an infringement suit against Cipla, which is pending in the courts. In the circumstances, the Controller General argued that this could not be an excuse for Bayer not ensuring adequate supply of Nexavar.<br /><br />A second important conclusion of the Controller is that the failure to meet demand adequately was partly caused by the high price of the product, which made it unaffordable. While Natco's counsel referred to research findings on reasonable estimates of R&D costs and the per capita incomes of the poor in India to argue that the product was unreasonably priced, the judgment itself focussed on the issue of unaffordability. Even when assessing this, the fundamental issue was not the fact that Nexavar was being priced at around Rs.2.8 lakh for a month's dosage of 120 tablets, when Cipla was supplying the drug at Rs.30,000 for a month's treatment, and Natco was promising the same quantum at Rs.8,800 if granted a licence.<br /><br />Rather, starting from the fact that the sale of Nexavar over the previous four years was only equivalent to a fraction of the public's estimated requirement of this life-extending treatment, Controller General Kurian concluded that the drug “was not bought by the public due to only one reason, that is, its price was not reasonably affordable to them”. This is an important precedent, since it lays down a condition for assessing affordability. If enough of a patented drug that is crucial for the public is not being actually consumed, it must reflect the fact that a significant share of patients are not able to afford the drug at the price at which it can be sold. That does warrant invoking the right to issue a CL.<br /><br />Finally, the judgment examined the issue of whether the patent was being fully worked in India, given that it was only being imported and not manufactured in the country. Counsel for Bayer referred to the fact that the phrase “manufactured in India” was dropped from the Patents Act when it was amended in 2002, to argue that local manufacture was not required to establish “working of a patent”.<br /><br />Moreover, Bayer's counsel argued, cost-effective scales of production of the drug were far above India's requirement. This precluded local manufacture, in which quality control was also difficult to ensure. Not accepting this argument but recognising that the Act does not define the phrase “worked in the territory of India”, the judgment turned to international conventions and the fact that the issue of local manufacture though removed from one context when the Indian Patents Act was amended was incorporated in another clause (Section 84(1)(c)).<br /><br />There are three points the judgment makes here. The first is that while importation rather than local manufacture is not a ground for forfeiture of a patent, a country may use the discretionary powers it has when framing patent legislation to make it a ground for invoking the right to compulsory licensing. Second, the understanding of working the patent in the relevant conventions does not imply working the patent on a “commercial scale”. And, finally but most importantly, “mere importation cannot amount to working of a patented innovation”.<br /><br />According to the judgment, “a patentee is obliged to contribute to the transfer and dissemination of the technology, nationally and internationally, so as to balance rights with obligations. A patentee can achieve this by either manufacturing the product in India or by granting a licence to any other person for manufacturing in India.” This conclusion, if sustained, is also a precedent with implications that go far beyond this case and product.<br /><br />On these grounds the Controller of Patents issued an order giving Natco the right to manufacture and sell a generic version of sorafenib tosylate, subject to pricing it at Rs.8,800 for a monthly dose of 120 tablets and the payment of 6 per cent royalty on the net sales to Bayer.<br /><br />As noted earlier, this judgment does mark a whole new phase in India's journey to fashion a patenting regime that would make medicines affordable to the common man. It is bound to be a precedent that will be quoted in a range of other cases and products. This is not because this is the first instance of grant of a CL, which itself is important. The failure to resort to compulsory licensing thus far was not because of lack of global precedent. In fact, developed countries such as Canada, the United Kingdom and Italy and developing countries such as Brazil, Thailand, Malaysia, South Africa and Kenya have resorted to such licensing in the case of drugs and pharmaceuticals. Very clearly, ideology and international pressure had held back the system.<br /><br />Controller General Kurian has initiated the process through which India can free itself of such fears and exercise its legitimate rights and options. The nation owes him much.</div>
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<br><a href="http://www.frontlineonnet.com/stories/20120504290801000.htm" class="re" target="_blank">Frontline, Volume 29, Issue 08, 21 April-04 May, 2012, http://www.frontlineonnet.com/stories/20120504290801000.htm</a><div class="clear"></div>
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That this is the first time a compulsory licence has been granted in India is in itself important.
INDIA'S long struggle to ensure access to affordable medicines for its people recently took a positive and interesting turn. In early March, just..." />
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<h1 class="cat-box-title">A big step forward-CP Chandrasekhar</h1>
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<br /><div align="justify"><em>That this is the first time a compulsory licence has been granted in India is in itself important.<br /></em><br />INDIA'S long struggle to ensure access to affordable medicines for its people recently took a positive and interesting turn. In early March, just before he demitted office, Controller General of Patents P.H. Kurian passed an order on an application filed by Natco Pharma, headquartered in Hyderabad, requesting a licence to produce an anti-cancer drug (sorafenib tosylate), the patent for which is held by the German pharmaceuticals and chemicals giant Bayer. It produces and markets the drug under the brand name Nexavar, which is used in the treatment of patients diagnosed as being in the advanced stages of affliction with liver or kidney cancer. Having failed to obtain a voluntary licence for manufacture from Bayer, Natco had filed an application under Section 84 of the Indian Patents Act, which specifies the conditions under which a “compulsory licence” (CL) may be issued to a producer other than the patentee. Compulsory licensing involves providing an agent, other than the holder of the patent for a product or process, permission to produce or market that product without the consent of the patent holder.<br /><br />Before 2005, when India amended its Patents Act to recognise product patents, Natco or any other Indian pharmaceutical company would not have needed such permission. All it needed to do was demonstrate that it had access to a process technology different from that used by Bayer to produce sorafenib. This encouraged the growth of an industry producing a large number of on-patent (and off-patent) drugs and marketing them at prices much lower than those charged by the original patentees. The net result was the well-documented fact that drug prices in India were among the lowest in the world and there was no shortage of essential drugs in the country.<br /><br />However, once India signed into the Uruguay Round Agreement, which included an agreement on Intellectual Property Rights (IPR), India's Patent Act, 1970, had to be amended thrice, in 1999, 2002 and 2005, to bring it in line with the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). These changes not only replaced the chapter on CLs but culminated in the recognition of product patents. Inasmuch as the latter prevented Indian firms from producing a patented product (unless the technology was voluntarily licensed by the patent holder) and gave the patent holder a monopoly right to produce the product, there was a danger that prices of medicines would rule high and attempts to regulate or control them could lead to inadequate availability of medicines.<br /><br />The TRIPS Agreement was to the disadvantage of less-industrialised developing countries like India, which had registered few patents, including in a crucial area like pharmaceuticals. However, the TRIPs Agreement did provide a few windows of opportunity for governments to intervene to rein in prices in support of needy patients in their countries. Crucial among them was the right (subject to conditions) that the agreement granted governments to resort to “compulsory licensing” on grounds such as the public interest, anti-competitive conduct, or need for non-commercial government use. It was that right that the clauses on CL in the revised Patent Act sought to interpret.<br /><br />What constitutes “public interest” is an issue of significance . In principle, the right of the government to resort to compulsory licensing can be invoked when the patent holder does not work the patent or does so in a manner that is inimical to the public interest, leading to “unreasonable prices”, inadequate technological progress, or inability to deal with public health or other emergencies. However, the TRIPSAgreement did require that the patentee should be notified about possible violations and the prospect of issue of a CL and that negotiations should be held with the patentee to resolve the issue if possible.<br /><br />In the case of pharmaceuticals, this right to issue a CL was strengthened under pressure from developing countries and civil society activists in the Doha Ministerial Declaration of 2001. The Declaration on the TRIPS Agreement and Public Health of 2001 affirmed the power of WTO members “to grant compulsory licences and the freedom to determine the grounds upon which such licences are granted” and held that the agreement “can and should be interpreted and implemented in a manner supportive of WTO Members' rights to protect public health and, in particular, to promote access to medicines for all”.<br /><br />In India these flexibilities became a matter for debate before the revision of the Patents Act was legislated to make it TRIPS-compliant, leading to major advances. One of those advances is the stipulation that a CL can be invoked also in instances where not only the patented product is not reasonably priced (say, relative to costs) but also the price is not reasonably affordable. Section 84 of the Indian Patents Act says: “At any time after the expiration of three years from the date of the grant of a patent, any person interested may make an application to the Controller for grant of compulsory licence on patent on any of the following grounds, namely: (a) that the reasonable requirements of the public with respect to the patented invention have not been satisfied, or (b) that the patented invention is not available to the public at a reasonably affordable price, or (c) that the patented invention is not worked in the territory of India.”<br /><br />What was unclear was how the presence or absence of such grounds for action were to be assessed. Remarkably, after India amended its Patents Act to make it TRIPS compliant and recognise product patents, the government had not, until now, exercised the right to compulsory licensing even once, which would have helped clarify matters. This is despite the fact that in a crucial public health-related area such as drugs and pharmaceuticals the transition to the new regime made a considerable difference to both availability and affordability.<br /><br />Being the first in itself makes the Nexavar judgment historic. But there is more to the judgment than its pioneering character. It is the grounds on which the Controller of Patents accepted Natco's application and rejected Bayer's opposition that are also path-breaking. One important ground was the assessment whether reasonable public requirement was being met with regard to the supply of Nexavar through importation. Noting that: (i) over the years, Bayer had imported the drug in volumes that could have treated only a small fraction (a little above 2 per cent) of those who could be credibly assessed as requiring the drug; (ii) that there were years in which no imports were made; and, (iii) that the company was relying only on the import route and not on local production to work the patent, the Controller General concluded that in a physical sense Bayer was not working the patent. It was not meeting the condition that “the reasonable requirements of the public with respect to the patented invention” were being satisfied.<br /><br />He also rejected the argument that these circumstances with respect to supply of Nexavar had to be judged in the context of the fact that Cipla, another domestic generic pharmaceuticals manufacturer, has without licence been marketing sorafenib in India at a price much lower than that charged by Bayer. Bayer has filed an infringement suit against Cipla, which is pending in the courts. In the circumstances, the Controller General argued that this could not be an excuse for Bayer not ensuring adequate supply of Nexavar.<br /><br />A second important conclusion of the Controller is that the failure to meet demand adequately was partly caused by the high price of the product, which made it unaffordable. While Natco's counsel referred to research findings on reasonable estimates of R&D costs and the per capita incomes of the poor in India to argue that the product was unreasonably priced, the judgment itself focussed on the issue of unaffordability. Even when assessing this, the fundamental issue was not the fact that Nexavar was being priced at around Rs.2.8 lakh for a month's dosage of 120 tablets, when Cipla was supplying the drug at Rs.30,000 for a month's treatment, and Natco was promising the same quantum at Rs.8,800 if granted a licence.<br /><br />Rather, starting from the fact that the sale of Nexavar over the previous four years was only equivalent to a fraction of the public's estimated requirement of this life-extending treatment, Controller General Kurian concluded that the drug “was not bought by the public due to only one reason, that is, its price was not reasonably affordable to them”. This is an important precedent, since it lays down a condition for assessing affordability. If enough of a patented drug that is crucial for the public is not being actually consumed, it must reflect the fact that a significant share of patients are not able to afford the drug at the price at which it can be sold. That does warrant invoking the right to issue a CL.<br /><br />Finally, the judgment examined the issue of whether the patent was being fully worked in India, given that it was only being imported and not manufactured in the country. Counsel for Bayer referred to the fact that the phrase “manufactured in India” was dropped from the Patents Act when it was amended in 2002, to argue that local manufacture was not required to establish “working of a patent”.<br /><br />Moreover, Bayer's counsel argued, cost-effective scales of production of the drug were far above India's requirement. This precluded local manufacture, in which quality control was also difficult to ensure. Not accepting this argument but recognising that the Act does not define the phrase “worked in the territory of India”, the judgment turned to international conventions and the fact that the issue of local manufacture though removed from one context when the Indian Patents Act was amended was incorporated in another clause (Section 84(1)(c)).<br /><br />There are three points the judgment makes here. The first is that while importation rather than local manufacture is not a ground for forfeiture of a patent, a country may use the discretionary powers it has when framing patent legislation to make it a ground for invoking the right to compulsory licensing. Second, the understanding of working the patent in the relevant conventions does not imply working the patent on a “commercial scale”. And, finally but most importantly, “mere importation cannot amount to working of a patented innovation”.<br /><br />According to the judgment, “a patentee is obliged to contribute to the transfer and dissemination of the technology, nationally and internationally, so as to balance rights with obligations. A patentee can achieve this by either manufacturing the product in India or by granting a licence to any other person for manufacturing in India.” This conclusion, if sustained, is also a precedent with implications that go far beyond this case and product.<br /><br />On these grounds the Controller of Patents issued an order giving Natco the right to manufacture and sell a generic version of sorafenib tosylate, subject to pricing it at Rs.8,800 for a monthly dose of 120 tablets and the payment of 6 per cent royalty on the net sales to Bayer.<br /><br />As noted earlier, this judgment does mark a whole new phase in India's journey to fashion a patenting regime that would make medicines affordable to the common man. It is bound to be a precedent that will be quoted in a range of other cases and products. This is not because this is the first instance of grant of a CL, which itself is important. The failure to resort to compulsory licensing thus far was not because of lack of global precedent. In fact, developed countries such as Canada, the United Kingdom and Italy and developing countries such as Brazil, Thailand, Malaysia, South Africa and Kenya have resorted to such licensing in the case of drugs and pharmaceuticals. Very clearly, ideology and international pressure had held back the system.<br /><br />Controller General Kurian has initiated the process through which India can free itself of such fears and exercise its legitimate rights and options. The nation owes him much.</div>
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<br><a href="http://www.frontlineonnet.com/stories/20120504290801000.htm" class="re" target="_blank">Frontline, Volume 29, Issue 08, 21 April-04 May, 2012, http://www.frontlineonnet.com/stories/20120504290801000.htm</a><div class="clear"></div>
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LATEST NEWS UPDATES | A big step forward-CP Chandrasekhar
Published on Apr 20, 2012
Modified on Apr 20, 2012
That this is the first time a compulsory licence has been granted in India is in itself important.
INDIA'S long struggle to ensure access to affordable medicines for its people recently took a positive and interesting turn. In early March, just before he demitted office, Controller General of Patents P.H. Kurian passed an order on an application filed by Natco Pharma, headquartered in Hyderabad, requesting a licence to produce an anti-cancer drug (sorafenib tosylate), the patent for which is held by the German pharmaceuticals and chemicals giant Bayer. It produces and markets the drug under the brand name Nexavar, which is used in the treatment of patients diagnosed as being in the advanced stages of affliction with liver or kidney cancer. Having failed to obtain a voluntary licence for manufacture from Bayer, Natco had filed an application under Section 84 of the Indian Patents Act, which specifies the conditions under which a “compulsory licence” (CL) may be issued to a producer other than the patentee. Compulsory licensing involves providing an agent, other than the holder of the patent for a product or process, permission to produce or market that product without the consent of the patent holder.
Before 2005, when India amended its Patents Act to recognise product patents, Natco or any other Indian pharmaceutical company would not have needed such permission. All it needed to do was demonstrate that it had access to a process technology different from that used by Bayer to produce sorafenib. This encouraged the growth of an industry producing a large number of on-patent (and off-patent) drugs and marketing them at prices much lower than those charged by the original patentees. The net result was the well-documented fact that drug prices in India were among the lowest in the world and there was no shortage of essential drugs in the country.
However, once India signed into the Uruguay Round Agreement, which included an agreement on Intellectual Property Rights (IPR), India's Patent Act, 1970, had to be amended thrice, in 1999, 2002 and 2005, to bring it in line with the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). These changes not only replaced the chapter on CLs but culminated in the recognition of product patents. Inasmuch as the latter prevented Indian firms from producing a patented product (unless the technology was voluntarily licensed by the patent holder) and gave the patent holder a monopoly right to produce the product, there was a danger that prices of medicines would rule high and attempts to regulate or control them could lead to inadequate availability of medicines.
The TRIPS Agreement was to the disadvantage of less-industrialised developing countries like India, which had registered few patents, including in a crucial area like pharmaceuticals. However, the TRIPs Agreement did provide a few windows of opportunity for governments to intervene to rein in prices in support of needy patients in their countries. Crucial among them was the right (subject to conditions) that the agreement granted governments to resort to “compulsory licensing” on grounds such as the public interest, anti-competitive conduct, or need for non-commercial government use. It was that right that the clauses on CL in the revised Patent Act sought to interpret.
What constitutes “public interest” is an issue of significance . In principle, the right of the government to resort to compulsory licensing can be invoked when the patent holder does not work the patent or does so in a manner that is inimical to the public interest, leading to “unreasonable prices”, inadequate technological progress, or inability to deal with public health or other emergencies. However, the TRIPSAgreement did require that the patentee should be notified about possible violations and the prospect of issue of a CL and that negotiations should be held with the patentee to resolve the issue if possible.
In the case of pharmaceuticals, this right to issue a CL was strengthened under pressure from developing countries and civil society activists in the Doha Ministerial Declaration of 2001. The Declaration on the TRIPS Agreement and Public Health of 2001 affirmed the power of WTO members “to grant compulsory licences and the freedom to determine the grounds upon which such licences are granted” and held that the agreement “can and should be interpreted and implemented in a manner supportive of WTO Members' rights to protect public health and, in particular, to promote access to medicines for all”.
In India these flexibilities became a matter for debate before the revision of the Patents Act was legislated to make it TRIPS-compliant, leading to major advances. One of those advances is the stipulation that a CL can be invoked also in instances where not only the patented product is not reasonably priced (say, relative to costs) but also the price is not reasonably affordable. Section 84 of the Indian Patents Act says: “At any time after the expiration of three years from the date of the grant of a patent, any person interested may make an application to the Controller for grant of compulsory licence on patent on any of the following grounds, namely: (a) that the reasonable requirements of the public with respect to the patented invention have not been satisfied, or (b) that the patented invention is not available to the public at a reasonably affordable price, or (c) that the patented invention is not worked in the territory of India.”
What was unclear was how the presence or absence of such grounds for action were to be assessed. Remarkably, after India amended its Patents Act to make it TRIPS compliant and recognise product patents, the government had not, until now, exercised the right to compulsory licensing even once, which would have helped clarify matters. This is despite the fact that in a crucial public health-related area such as drugs and pharmaceuticals the transition to the new regime made a considerable difference to both availability and affordability.
Being the first in itself makes the Nexavar judgment historic. But there is more to the judgment than its pioneering character. It is the grounds on which the Controller of Patents accepted Natco's application and rejected Bayer's opposition that are also path-breaking. One important ground was the assessment whether reasonable public requirement was being met with regard to the supply of Nexavar through importation. Noting that: (i) over the years, Bayer had imported the drug in volumes that could have treated only a small fraction (a little above 2 per cent) of those who could be credibly assessed as requiring the drug; (ii) that there were years in which no imports were made; and, (iii) that the company was relying only on the import route and not on local production to work the patent, the Controller General concluded that in a physical sense Bayer was not working the patent. It was not meeting the condition that “the reasonable requirements of the public with respect to the patented invention” were being satisfied.
He also rejected the argument that these circumstances with respect to supply of Nexavar had to be judged in the context of the fact that Cipla, another domestic generic pharmaceuticals manufacturer, has without licence been marketing sorafenib in India at a price much lower than that charged by Bayer. Bayer has filed an infringement suit against Cipla, which is pending in the courts. In the circumstances, the Controller General argued that this could not be an excuse for Bayer not ensuring adequate supply of Nexavar.
A second important conclusion of the Controller is that the failure to meet demand adequately was partly caused by the high price of the product, which made it unaffordable. While Natco's counsel referred to research findings on reasonable estimates of R&D costs and the per capita incomes of the poor in India to argue that the product was unreasonably priced, the judgment itself focussed on the issue of unaffordability. Even when assessing this, the fundamental issue was not the fact that Nexavar was being priced at around Rs.2.8 lakh for a month's dosage of 120 tablets, when Cipla was supplying the drug at Rs.30,000 for a month's treatment, and Natco was promising the same quantum at Rs.8,800 if granted a licence.
Rather, starting from the fact that the sale of Nexavar over the previous four years was only equivalent to a fraction of the public's estimated requirement of this life-extending treatment, Controller General Kurian concluded that the drug “was not bought by the public due to only one reason, that is, its price was not reasonably affordable to them”. This is an important precedent, since it lays down a condition for assessing affordability. If enough of a patented drug that is crucial for the public is not being actually consumed, it must reflect the fact that a significant share of patients are not able to afford the drug at the price at which it can be sold. That does warrant invoking the right to issue a CL.
Finally, the judgment examined the issue of whether the patent was being fully worked in India, given that it was only being imported and not manufactured in the country. Counsel for Bayer referred to the fact that the phrase “manufactured in India” was dropped from the Patents Act when it was amended in 2002, to argue that local manufacture was not required to establish “working of a patent”.
Moreover, Bayer's counsel argued, cost-effective scales of production of the drug were far above India's requirement. This precluded local manufacture, in which quality control was also difficult to ensure. Not accepting this argument but recognising that the Act does not define the phrase “worked in the territory of India”, the judgment turned to international conventions and the fact that the issue of local manufacture though removed from one context when the Indian Patents Act was amended was incorporated in another clause (Section 84(1)(c)).
There are three points the judgment makes here. The first is that while importation rather than local manufacture is not a ground for forfeiture of a patent, a country may use the discretionary powers it has when framing patent legislation to make it a ground for invoking the right to compulsory licensing. Second, the understanding of working the patent in the relevant conventions does not imply working the patent on a “commercial scale”. And, finally but most importantly, “mere importation cannot amount to working of a patented innovation”.
According to the judgment, “a patentee is obliged to contribute to the transfer and dissemination of the technology, nationally and internationally, so as to balance rights with obligations. A patentee can achieve this by either manufacturing the product in India or by granting a licence to any other person for manufacturing in India.” This conclusion, if sustained, is also a precedent with implications that go far beyond this case and product.
On these grounds the Controller of Patents issued an order giving Natco the right to manufacture and sell a generic version of sorafenib tosylate, subject to pricing it at Rs.8,800 for a monthly dose of 120 tablets and the payment of 6 per cent royalty on the net sales to Bayer.
As noted earlier, this judgment does mark a whole new phase in India's journey to fashion a patenting regime that would make medicines affordable to the common man. It is bound to be a precedent that will be quoted in a range of other cases and products. This is not because this is the first instance of grant of a CL, which itself is important. The failure to resort to compulsory licensing thus far was not because of lack of global precedent. In fact, developed countries such as Canada, the United Kingdom and Italy and developing countries such as Brazil, Thailand, Malaysia, South Africa and Kenya have resorted to such licensing in the case of drugs and pharmaceuticals. Very clearly, ideology and international pressure had held back the system.
Controller General Kurian has initiated the process through which India can free itself of such fears and exercise its legitimate rights and options. The nation owes him much.
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