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LATEST NEWS UPDATES | How co-morbidities make COVID severe -T Jacob John and MS Seshadri

How co-morbidities make COVID severe -T Jacob John and MS Seshadri

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published Published on Jan 19, 2021   modified Modified on Jan 19, 2021

-The Hindu

Physicians are confronted with a complex problem that involves multiple organ systems

Medical students are taught to classify diseases as either congenital or acquired. Acquired diseases are infectious or inflammatory, nutritional or metabolic, vascular or neoplastic (tumours, benign or malignant). COVID-19 is acquired, infectious/inflammatory. The microbe is SARS-CoV-2.

What are co-morbidities and why do they make COVID-19 severe and life-threatening? Chronic nutritional/metabolic diseases start as diabetes, hypertension, metabolic syndrome or obesity. They in turn lead to chronic heart, brain and kidney diseases because of damage to the lining cells of the blood vessels, the ‘endothelium’. For someone with an acute disease, a pre-existing chronic disease is now a co-morbidity.

The immune system is highly conserved even in undernourished people; the impact of co-morbidities on the immune system is mild. Exceptions occur: TB is more common in undernourished adults and uncontrolled diabetes; metabolic syndrome, however, is associated with over-nutrition. If someone with a co-morbidity gets COVID-19, the disease severity is increased out of proportion to any subtle or mild effect of the co-morbidity on the immune system.

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The Hindu, 19 January, 2021, https://www.thehindu.com/opinion/op-ed/how-co-morbidities-make-covid-severe/article33602642.ece?homepage=true


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