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LATEST NEWS UPDATES | Last-resort antibiotic sales jump -GS Mudur

Last-resort antibiotic sales jump -GS Mudur

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published Published on Oct 16, 2017   modified Modified on Oct 16, 2017
-The Telegraph

New Delhi: The sale of drug combinations containing last-resort antibiotics is rising faster than overall antibiotics sales in India, health researchers have said in a study that also highlights the government's failure to stop the sale of irrational and unapproved antibiotic cocktails.

While total antibiotics sales in India rose 26 per cent over a four-year period, says the study, there was a 174 per cent increase in the sales of drug combinations containing antibiotics that should be used only after other medicines have failed.

Many of the so-called fixed-dose combinations of antibiotics have not been approved by the Central Drugs Standards Control Organisation, the country's apex drug regulatory agency, and should thus be considered illegal drugs, the researchers said.

Although the drug regulator had acknowledged the problem and banned dozens of fixed-dose combinations, including antibiotic combinations, last year, most of these drugs remain in the market with their companies getting the ban quashed in court.

The recent study, by British and Indian researchers, examined antibiotics sales between 2008 and 2012 and found that 75 (64 per cent) among 118 fixed-dose combinations of antibiotics sold in India lacked regulatory approval, while 43 (36 per cent) had the approval. The findings were published this week in the journal Lancet Global Health.

Only five of the 43 approved fixed-dose combinations have also been approved by drug regulators in Britain and America.

"The sales of antibiotics that require the most careful control and regulation are increasing at the fastest rate," Patricia McGettigan, a clinical pharmacologist at the Queen Mary University of London who led the study, said in a media release.

"Even worse, many (of these) formulations had never been approved by the national drug regulator."

The study has found that:

• Sales of fixed-dose combinations containing antibiotics that the World Health Organisation has classified as "key access" (which should be widely available) increased by about 20 per cent over the four-year period;
Sales of fixed-dose combinations with antibiotics that the WHO has labelled "watch group" (which should be used restrictively for a small number of infections) grew at 73 per cent; and

• Sales of fixed-dose combinations containing antibiotics from the WHO's "reserve group" (last-resort antibiotics) grew by 174 per cent.

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The Telegraph, 16 October, 2017, https://www.telegraphindia.com/india/last-resort-antibiotic-sales-jump-178696


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