Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 150
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::index() - APP/Controller/ArtileDetailController.php, line 150
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 151
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::index() - APP/Controller/ArtileDetailController.php, line 151
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 610
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 162
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\AssetMiddleware::__invoke() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 97
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Warning (512): Unable to emit headers. Headers sent in file=/home/brlfuser/public_html/vendor/cakephp/cakephp/src/Error/Debugger.php line=853 [CORE/src/Http/ResponseEmitter.php, line 48]
Code Context
            if (Configure::read('debug')) {

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        LATEST NEWS UPDATES | Was U.S. baby infected with HIV at all? -R Prasad    </title>
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-The Hindu

Chennai: A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.

&ldquo;There are many instances where the mother&rsquo;s HIV..."/>
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-The Hindu

Chennai: A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.

&ldquo;There are many instances where the mother&rsquo;s HIV..." />
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                            <div align="justify">-The Hindu<br /><br /><em>Chennai: </em>A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.<br /><br />&ldquo;There are many instances where the mother&rsquo;s HIV particles (HIV RNA) can be present in the newborn&rsquo;s blood,&rdquo; Dr. N. Kumarasamy told this correspondent from Atlanta, U.S.<br /><br />Dr. Kumarasamy is the Chief Medical Officer at YRGCARE, Chennai, and is currently attending the annual conference on Retroviruses and Opportunistic Infections in Atlanta. The results of the Mississippian baby were presented on Monday.<br /><br />&ldquo;Mother&rsquo;s HIV particles can disappear from the newborn on their own without causing the disease. It can happen within four months of age,&rdquo; he said. So was the HIV-positive status of the baby a wrong diagnosis? More studies are therefore needed to confirm that the baby was indeed HIV-positive when ART was initiated just 30 hours after the birth and continued till the age of 18 months. The only way to distinguish a mother&rsquo;s HIV particles from that of a baby is by comparing their viruses by doing a genetic analysis.<br /><br />But the biggest weakness of the study appears to be the absence of the mother&rsquo;s antibodies in the baby&rsquo;s blood after some time. Mothers can infect the babies with HIV anytime during pregnancy but mostly in the last few days. Antibodies develop soon after infection. &ldquo;Even if the baby was cured of HIV, we expect the mother&rsquo;s antibodies also to be present in the infant up to 18 months,&rdquo; Dr. Kumarasamy said. &ldquo;This greatly weakens the study finding.&rdquo;<br /><br />The absence of antibodies to HIV was not disclosed to the press by the researchers when the results of the study were reported on March 3.<br /><br />According to the abstract of the paper, the HIV-positive status of the baby was confirmed by HIV DNA and RNA testing on &ldquo;two separate blood samples obtained on the second day of life.&rdquo; Three &ldquo;additional plasma viral load tests (days of life seven, 12 and 20) were positive before reaching undetectable levels at age 29 days,&rdquo; the abstract states.<br /><br /><em>&ldquo;Undetectable levels&rdquo;<br /></em><br />Apparently, HIV RNA has remained at &ldquo;undetectable&rdquo; levels on 16 different measurements obtained between one and 26 months of age. This despite the discontinuation of treatment at 18 months. HIV DNA copies also came down to four copies per million peripheral blood mononuclear cells present at the age of 26 months.<br /><br />This led the researchers to conclude that the Mississippian baby was the &ldquo;first well-documented case of functional cure in an HIV-positive child.&rdquo; <br /><br /></div>                                                           
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    <br><a href="http://www.thehindu.com/sci-tech/health/was-us-baby-infected-with-hiv-at-all/article4482592.ece" class="re" target="_blank">The Hindu, 7 March, 2013, http://www.thehindu.com/sci-tech/health/was-us-baby-infected-with-hiv-at-all/article4482592.ece</a><div class="clear"></div>
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Chennai: A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.

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    <h1 class="cat-box-title">Was U.S. baby infected with HIV at all? -R Prasad</h1>
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                            <div align="justify">-The Hindu<br /><br /><em>Chennai: </em>A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.<br /><br />&ldquo;There are many instances where the mother&rsquo;s HIV particles (HIV RNA) can be present in the newborn&rsquo;s blood,&rdquo; Dr. N. Kumarasamy told this correspondent from Atlanta, U.S.<br /><br />Dr. Kumarasamy is the Chief Medical Officer at YRGCARE, Chennai, and is currently attending the annual conference on Retroviruses and Opportunistic Infections in Atlanta. The results of the Mississippian baby were presented on Monday.<br /><br />&ldquo;Mother&rsquo;s HIV particles can disappear from the newborn on their own without causing the disease. It can happen within four months of age,&rdquo; he said. So was the HIV-positive status of the baby a wrong diagnosis? More studies are therefore needed to confirm that the baby was indeed HIV-positive when ART was initiated just 30 hours after the birth and continued till the age of 18 months. The only way to distinguish a mother&rsquo;s HIV particles from that of a baby is by comparing their viruses by doing a genetic analysis.<br /><br />But the biggest weakness of the study appears to be the absence of the mother&rsquo;s antibodies in the baby&rsquo;s blood after some time. Mothers can infect the babies with HIV anytime during pregnancy but mostly in the last few days. Antibodies develop soon after infection. &ldquo;Even if the baby was cured of HIV, we expect the mother&rsquo;s antibodies also to be present in the infant up to 18 months,&rdquo; Dr. Kumarasamy said. &ldquo;This greatly weakens the study finding.&rdquo;<br /><br />The absence of antibodies to HIV was not disclosed to the press by the researchers when the results of the study were reported on March 3.<br /><br />According to the abstract of the paper, the HIV-positive status of the baby was confirmed by HIV DNA and RNA testing on &ldquo;two separate blood samples obtained on the second day of life.&rdquo; Three &ldquo;additional plasma viral load tests (days of life seven, 12 and 20) were positive before reaching undetectable levels at age 29 days,&rdquo; the abstract states.<br /><br /><em>&ldquo;Undetectable levels&rdquo;<br /></em><br />Apparently, HIV RNA has remained at &ldquo;undetectable&rdquo; levels on 16 different measurements obtained between one and 26 months of age. This despite the discontinuation of treatment at 18 months. HIV DNA copies also came down to four copies per million peripheral blood mononuclear cells present at the age of 26 months.<br /><br />This led the researchers to conclude that the Mississippian baby was the &ldquo;first well-documented case of functional cure in an HIV-positive child.&rdquo; <br /><br /></div>                                                           
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    <br><a href="http://www.thehindu.com/sci-tech/health/was-us-baby-infected-with-hiv-at-all/article4482592.ece" class="re" target="_blank">The Hindu, 7 March, 2013, http://www.thehindu.com/sci-tech/health/was-us-baby-infected-with-hiv-at-all/article4482592.ece</a><div class="clear"></div>
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        LATEST NEWS UPDATES | Was U.S. baby infected with HIV at all? -R Prasad    </title>
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-The Hindu

Chennai: A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.

&ldquo;There are many instances where the mother&rsquo;s HIV..."/>
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-The Hindu

Chennai: A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.

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    <h1 class="cat-box-title">Was U.S. baby infected with HIV at all? -R Prasad</h1>
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                            <div align="justify">-The Hindu<br /><br /><em>Chennai: </em>A few days after the news broke of a &ldquo;functional cure&rdquo; in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV.<br /><br />&ldquo;There are many instances where the mother&rsquo;s HIV particles (HIV RNA) can be present in the newborn&rsquo;s blood,&rdquo; Dr. N. Kumarasamy told this correspondent from Atlanta, U.S.<br /><br />Dr. Kumarasamy is the Chief Medical Officer at YRGCARE, Chennai, and is currently attending the annual conference on Retroviruses and Opportunistic Infections in Atlanta. The results of the Mississippian baby were presented on Monday.<br /><br />&ldquo;Mother&rsquo;s HIV particles can disappear from the newborn on their own without causing the disease. It can happen within four months of age,&rdquo; he said. So was the HIV-positive status of the baby a wrong diagnosis? More studies are therefore needed to confirm that the baby was indeed HIV-positive when ART was initiated just 30 hours after the birth and continued till the age of 18 months. The only way to distinguish a mother&rsquo;s HIV particles from that of a baby is by comparing their viruses by doing a genetic analysis.<br /><br />But the biggest weakness of the study appears to be the absence of the mother&rsquo;s antibodies in the baby&rsquo;s blood after some time. Mothers can infect the babies with HIV anytime during pregnancy but mostly in the last few days. Antibodies develop soon after infection. &ldquo;Even if the baby was cured of HIV, we expect the mother&rsquo;s antibodies also to be present in the infant up to 18 months,&rdquo; Dr. Kumarasamy said. &ldquo;This greatly weakens the study finding.&rdquo;<br /><br />The absence of antibodies to HIV was not disclosed to the press by the researchers when the results of the study were reported on March 3.<br /><br />According to the abstract of the paper, the HIV-positive status of the baby was confirmed by HIV DNA and RNA testing on &ldquo;two separate blood samples obtained on the second day of life.&rdquo; Three &ldquo;additional plasma viral load tests (days of life seven, 12 and 20) were positive before reaching undetectable levels at age 29 days,&rdquo; the abstract states.<br /><br /><em>&ldquo;Undetectable levels&rdquo;<br /></em><br />Apparently, HIV RNA has remained at &ldquo;undetectable&rdquo; levels on 16 different measurements obtained between one and 26 months of age. This despite the discontinuation of treatment at 18 months. HIV DNA copies also came down to four copies per million peripheral blood mononuclear cells present at the age of 26 months.<br /><br />This led the researchers to conclude that the Mississippian baby was the &ldquo;first well-documented case of functional cure in an HIV-positive child.&rdquo; <br /><br /></div>                                                           
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    <br><a href="http://www.thehindu.com/sci-tech/health/was-us-baby-infected-with-hiv-at-all/article4482592.ece" class="re" target="_blank">The Hindu, 7 March, 2013, http://www.thehindu.com/sci-tech/health/was-us-baby-infected-with-hiv-at-all/article4482592.ece</a><div class="clear"></div>
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Home हिन्दी

Was U.S. baby infected with HIV at all? -R Prasad

Published on Mar 7, 2013   Modified on Mar 7, 2013

-The Hindu Chennai: A few days after the news broke of a “functional cure” in a HIV-positive Mississippian baby aged two-and-a-half, many questions have been raised whether the baby was indeed infected with HIV. “There are many instances where the mother’s HIV particles (HIV RNA) can be present in the newborn’s blood,” Dr. N. Kumarasamy told this correspondent from Atlanta, U.S. Dr. Kumarasamy is the Chief Medical Officer at YRGCARE, Chennai, and is currently attending the annual conference on Retroviruses and Opportunistic Infections in Atlanta. The results of the Mississippian baby were presented on Monday. “Mother’s HIV particles can disappear from the newborn on their own without causing the disease. It can happen within four months of age,” he said. So was the HIV-positive status of the baby a wrong diagnosis? More studies are therefore needed to confirm that the baby was indeed HIV-positive when ART was initiated just 30 hours after the birth and continued till the age of 18 months. The only way to distinguish a mother’s HIV particles from that of a baby is by comparing their viruses by doing a genetic analysis. But the biggest weakness of the study appears to be the absence of the mother’s antibodies in the baby’s blood after some time. Mothers can infect the babies with HIV anytime during pregnancy but mostly in the last few days. Antibodies develop soon after infection. “Even if the baby was cured of HIV, we expect the mother’s antibodies also to be present in the infant up to 18 months,” Dr. Kumarasamy said. “This greatly weakens the study finding.” The absence of antibodies to HIV was not disclosed to the press by the researchers when the results of the study were reported on March 3. According to the abstract of the paper, the HIV-positive status of the baby was confirmed by HIV DNA and RNA testing on “two separate blood samples obtained on the second day of life.” Three “additional plasma viral load tests (days of life seven, 12 and 20) were positive before reaching undetectable levels at age 29 days,” the abstract states. “Undetectable levels” Apparently, HIV RNA has remained at “undetectable” levels on 16 different measurements obtained between one and 26 months of age. This despite the discontinuation of treatment at 18 months. HIV DNA copies also came down to four copies per million peripheral blood mononuclear cells present at the age of 26 months. This led the researchers to conclude that the Mississippian baby was the “first well-documented case of functional cure in an HIV-positive child.”

The Hindu, 7 March, 2013, http://www.thehindu.com/sci-tech/health/was-us-baby-infected-with-hiv-at-all/article4482592.ece

Tagged with: HIV AIDS Health

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