Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 150
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::index() - APP/Controller/ArtileDetailController.php, line 150
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Deprecated (16384): The ArrayAccess methods will be removed in 4.0.0.Use getParam(), getData() and getQuery() instead. - /home/brlfuser/public_html/src/Controller/ArtileDetailController.php, line: 151
 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php. [CORE/src/Core/functions.php, line 311]
Code Context


        trigger_error($message, E_USER_DEPRECATED);

    }
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 You can disable deprecation warnings by setting `Error.errorLevel` to `E_ALL & ~E_USER_DEPRECATED` in your config/app.php.'
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deprecationWarning - CORE/src/Core/functions.php, line 311
Cake\Http\ServerRequest::offsetGet() - CORE/src/Http/ServerRequest.php, line 2421
App\Controller\ArtileDetailController::index() - APP/Controller/ArtileDetailController.php, line 151
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 610
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 120
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 162
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\AssetMiddleware::__invoke() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 97
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Error\Middleware\ErrorHandlerMiddleware::__invoke() - CORE/src/Error/Middleware/ErrorHandlerMiddleware.php, line 96
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 98

Warning (512): Unable to emit headers. Headers sent in file=/home/brlfuser/public_html/vendor/cakephp/cakephp/src/Error/Debugger.php line=853 [CORE/src/Http/ResponseEmitter.php, line 48]
Code Context
            if (Configure::read('debug')) {

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        LATEST NEWS UPDATES | Genetic changes protect primitive Indian tribes from malaria -Y Mallikarjun    </title>
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-The Hindu





Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.





Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of..."/>
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-The Hindu





Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.





Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of..." />
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                            <div style="text-align: justify">-The Hindu</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of an infected mosquito.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">While it is known that mutations in genes could lead to genetic diseases, scientists have studied whether genetic variations would lead to either susceptibility to malaria or resistance against the disease.</div><div style="text-align: justify"><br /></div><div style="text-align: justify"><em>Samples</em></div><div style="text-align: justify"><br /></div><div style="text-align: justify">Initially, samples were collected from patients suffering from the disease from malaria-endemic regions of Chhattisgarh and Odisha as also from normal population in those areas to see if there were any differences among them at genetic level.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Although genetic variations in Interleukin-4 (IL-4), an anti-inflammatory gene have been reported to affect the risk of infectious and auto-immune diseases, this was the first study to look into its contribution in malaria, according to Kumaraswamy Thangaraj, senior author of the study and Deputy Director, the Centre for Cellular and Molecular Biology.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Beside the CCMB, nine other research and academic institutions from India and abroad, including Germany, Vietnam, Syria and Brazil were involved in the study, which was published online in PLOS One journal.</div><div style="text-align: justify"><br /></div><div style="text-align: justify"><em>Variations in IL-4</em></div><div style="text-align: justify"><br /></div><div style="text-align: justify">In this study, 4,216 individuals, a majority from India and the rest from Brazil, Vietnam and Syria were investigated for three specific variations in IL-4. The study subjects from India included different tribes, castes and linguistic groups. The variation, which gave resistance against malaria was found to be in the primitive Indian tribal population as compared to other caste and tribal groups.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Dr. Thangaraj said since primitive tribal population were living in remote places without the aid of modern facilities against mosquito bite, they have been exposed to various parasites over hundreds of years.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">This exposure over a long period must have automatically led to some mechanism to protect against malaria through the process of natural selection.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">He said the findings would help in screening populations for susceptibility and resistance to malaria.</div>                                                           
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    <br><a href="http://www.thehindu.com/todays-paper/tp-national/genetic-changes-protect-primitive-indian-tribes-from-malaria/article4079556.ece" class="re" target="_blank">The Hindu, 9 November, 2012, http://www.thehindu.com/todays-paper/tp-national/genetic-changes-protect-primitive-indian-tribes-from-malaria/article4079556.ece</a><div class="clear"></div>
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        LATEST NEWS UPDATES | Genetic changes protect primitive Indian tribes from malaria -Y Mallikarjun    </title>
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Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.





Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of..."/>
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-The Hindu





Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.





Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of..." />
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    <h1 class="cat-box-title">Genetic changes protect primitive Indian tribes from malaria -Y Mallikarjun</h1>
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                            <div style="text-align: justify">-The Hindu</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of an infected mosquito.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">While it is known that mutations in genes could lead to genetic diseases, scientists have studied whether genetic variations would lead to either susceptibility to malaria or resistance against the disease.</div><div style="text-align: justify"><br /></div><div style="text-align: justify"><em>Samples</em></div><div style="text-align: justify"><br /></div><div style="text-align: justify">Initially, samples were collected from patients suffering from the disease from malaria-endemic regions of Chhattisgarh and Odisha as also from normal population in those areas to see if there were any differences among them at genetic level.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Although genetic variations in Interleukin-4 (IL-4), an anti-inflammatory gene have been reported to affect the risk of infectious and auto-immune diseases, this was the first study to look into its contribution in malaria, according to Kumaraswamy Thangaraj, senior author of the study and Deputy Director, the Centre for Cellular and Molecular Biology.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Beside the CCMB, nine other research and academic institutions from India and abroad, including Germany, Vietnam, Syria and Brazil were involved in the study, which was published online in PLOS One journal.</div><div style="text-align: justify"><br /></div><div style="text-align: justify"><em>Variations in IL-4</em></div><div style="text-align: justify"><br /></div><div style="text-align: justify">In this study, 4,216 individuals, a majority from India and the rest from Brazil, Vietnam and Syria were investigated for three specific variations in IL-4. The study subjects from India included different tribes, castes and linguistic groups. The variation, which gave resistance against malaria was found to be in the primitive Indian tribal population as compared to other caste and tribal groups.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Dr. Thangaraj said since primitive tribal population were living in remote places without the aid of modern facilities against mosquito bite, they have been exposed to various parasites over hundreds of years.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">This exposure over a long period must have automatically led to some mechanism to protect against malaria through the process of natural selection.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">He said the findings would help in screening populations for susceptibility and resistance to malaria.</div>                                                           
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    <br><a href="http://www.thehindu.com/todays-paper/tp-national/genetic-changes-protect-primitive-indian-tribes-from-malaria/article4079556.ece" class="re" target="_blank">The Hindu, 9 November, 2012, http://www.thehindu.com/todays-paper/tp-national/genetic-changes-protect-primitive-indian-tribes-from-malaria/article4079556.ece</a><div class="clear"></div>
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        LATEST NEWS UPDATES | Genetic changes protect primitive Indian tribes from malaria -Y Mallikarjun    </title>
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-The Hindu





Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.





Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of..."/>
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-The Hindu





Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.





Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of..." />
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    <h1 class="cat-box-title">Genetic changes protect primitive Indian tribes from malaria -Y Mallikarjun</h1>
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                            <div style="text-align: justify">-The Hindu</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of an infected mosquito.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">While it is known that mutations in genes could lead to genetic diseases, scientists have studied whether genetic variations would lead to either susceptibility to malaria or resistance against the disease.</div><div style="text-align: justify"><br /></div><div style="text-align: justify"><em>Samples</em></div><div style="text-align: justify"><br /></div><div style="text-align: justify">Initially, samples were collected from patients suffering from the disease from malaria-endemic regions of Chhattisgarh and Odisha as also from normal population in those areas to see if there were any differences among them at genetic level.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Although genetic variations in Interleukin-4 (IL-4), an anti-inflammatory gene have been reported to affect the risk of infectious and auto-immune diseases, this was the first study to look into its contribution in malaria, according to Kumaraswamy Thangaraj, senior author of the study and Deputy Director, the Centre for Cellular and Molecular Biology.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Beside the CCMB, nine other research and academic institutions from India and abroad, including Germany, Vietnam, Syria and Brazil were involved in the study, which was published online in PLOS One journal.</div><div style="text-align: justify"><br /></div><div style="text-align: justify"><em>Variations in IL-4</em></div><div style="text-align: justify"><br /></div><div style="text-align: justify">In this study, 4,216 individuals, a majority from India and the rest from Brazil, Vietnam and Syria were investigated for three specific variations in IL-4. The study subjects from India included different tribes, castes and linguistic groups. The variation, which gave resistance against malaria was found to be in the primitive Indian tribal population as compared to other caste and tribal groups.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">Dr. Thangaraj said since primitive tribal population were living in remote places without the aid of modern facilities against mosquito bite, they have been exposed to various parasites over hundreds of years.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">This exposure over a long period must have automatically led to some mechanism to protect against malaria through the process of natural selection.</div><div style="text-align: justify"><br /></div><div style="text-align: justify">He said the findings would help in screening populations for susceptibility and resistance to malaria.</div>                                                           
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    <br><a href="http://www.thehindu.com/todays-paper/tp-national/genetic-changes-protect-primitive-indian-tribes-from-malaria/article4079556.ece" class="re" target="_blank">The Hindu, 9 November, 2012, http://www.thehindu.com/todays-paper/tp-national/genetic-changes-protect-primitive-indian-tribes-from-malaria/article4079556.ece</a><div class="clear"></div>
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Genetic changes protect primitive Indian tribes from malaria -Y Mallikarjun

Published on Nov 9, 2012   Modified on Nov 9, 2012

-The Hindu Certain genetic variations among primitive Indian tribal populations were found to be shielding them against malaria, a new study has found. Malaria claims thousands of lives across the globe annually and is caused by parasite Plasmodium through the bite of an infected mosquito. While it is known that mutations in genes could lead to genetic diseases, scientists have studied whether genetic variations would lead to either susceptibility to malaria or resistance against the disease. Samples Initially, samples were collected from patients suffering from the disease from malaria-endemic regions of Chhattisgarh and Odisha as also from normal population in those areas to see if there were any differences among them at genetic level. Although genetic variations in Interleukin-4 (IL-4), an anti-inflammatory gene have been reported to affect the risk of infectious and auto-immune diseases, this was the first study to look into its contribution in malaria, according to Kumaraswamy Thangaraj, senior author of the study and Deputy Director, the Centre for Cellular and Molecular Biology. Beside the CCMB, nine other research and academic institutions from India and abroad, including Germany, Vietnam, Syria and Brazil were involved in the study, which was published online in PLOS One journal. Variations in IL-4 In this study, 4,216 individuals, a majority from India and the rest from Brazil, Vietnam and Syria were investigated for three specific variations in IL-4. The study subjects from India included different tribes, castes and linguistic groups. The variation, which gave resistance against malaria was found to be in the primitive Indian tribal population as compared to other caste and tribal groups. Dr. Thangaraj said since primitive tribal population were living in remote places without the aid of modern facilities against mosquito bite, they have been exposed to various parasites over hundreds of years. This exposure over a long period must have automatically led to some mechanism to protect against malaria through the process of natural selection. He said the findings would help in screening populations for susceptibility and resistance to malaria.

The Hindu, 9 November, 2012, http://www.thehindu.com/todays-paper/tp-national/genetic-changes-protect-primitive-indian-tribes-from-malaria/article4079556.ece

Tagged with: malaria Health

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